
NCBI . NLM . NIH . GOV {
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Title[redir]:
Recruitment of myeloid but not endothelial precursor cells facilitates tumor re-growth after local irradiation - PMC
Description:
Tumor neovascularization and growth may be promoted by recruitment of bone marrow-derived cells (BMDCs), which include endothelial precursor cells (EPCs) and “vascular modulatory” myelomonocytic (CD11b+) cells. BMDCs may also drive tumor re-growth ...
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Keywords {🔍}
tumor, tumors, doi, irradiation, cells, bmdcs, wbi, pubmed, google, scholar, regrowth, pmc, fig, myeloid, growth, sdfα, mice, significantly, cancer, recruitment, article, mca, endothelial, bone, cdb, effect, radiation, supplementary, cell, local, epcs, role, bmdc, compared, cxcr, infiltration, analysis, data, free, increased, days, treatment, recurring, nlm, dose, expression, significant, nonirradiated, res, models,
Topics {✒️}
tgf-beta-dependent hif-1alpha-mediated induction chimeric wt/tie2-gfp-bmt mice wt/tie2-gfp-bmt mice tie2-gfp-labeled bmdc population vessel-incorporated tie2+cd31+cd11b− epcs nih grants p01-ca80124 pmc beta search bone marrow-derived cells nih grant r01-ca115767 tie2-gfp-fvb donors lsr-ii flow cytometer therapy-induced acute recruitment host-derived bmdc infiltration fluorescence-labeled monoclonal antibodies �vascular modulatory/accessory” cells alzet micro-osmotic pumps single-cell suspensions prepared pan-myeloid marker cd11b facs-sorted sca1−cd11b+ tumor post-radiation dynamics vegf-induced adult neovascularization sdf-1α receptor cxcr4 sdf-1α-cxcr4 pathway sdf-1α/cxcr4 signaling sdf-1α-cxcr4 signaling treated tumor-bearing mice regulates sdf-1α expression intratumoral sdf-1α triggered li-induced macrophage infiltration hif-1alpha stability pre-irradiated normal tissues radiation-naïve tumor growth endothelial precursor cells �vascular modulatory” myelomonocytic bone marrow cells host-derived cells overlapping effects post-irradiation endothelial marker cd31 hif-1α activation haematopoietic progenitor cells myeloid bmdcs post-li local control probability tumor angiogenesis post-li irradiated endothelial cells license information pmcid distinct immune profiles haematopoietic stem cells tie2-gfp+ bmdcs vascular-modulatory tems sdf-1 induces revascularization
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- Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
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