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Keywords {🔍}

cells, mice, doi, kbxn, pubmed, google, scholar, cell, spf, arthritis, fig, pmc, disease, gut, bacteria, article, gpi, data, experiments, free, intestinal, silp, sfb, autoimmune, immune, independent, ivanov, values, splenocytes, bxn, commensal, model, splenic, system, titers, total, development, flow, day, cytometry, immunol, conditions, representative, isolated, filamentous, microbes, mouse, animals, ankle, analyzed,

Topics {✒️}

ra vis-à-vis controls vis-à-vis bxn controls gf vis-à-vis spf danger-free autoimmune disease mesenteric lymph nodes ctl-immunospot® uv analyzer b220-conjugated macs beads tumor necrosis factor-α vis-à-vis pmc beta search transgene-encoded tcr recognize gene-specific fluorogenic assays gene encoding interferon-γ spore-forming obligate anaerobes anti-cd3/cd28 beads tissue-selective lymphocyte trafficking conjugated anti-mouse igg results germ-free niddk-funded derc cores disrupted interferon-gamma genes augment autoantibody-induced arthritis small-intestinal lamina-propria gpi ab-secreting cells multi-organ auto-inflammation experimental procedures mice fluorophore-labeled mabs specific sfb-related clostridiaceae family specific-pathogen-free germ-free mouse organ-specific autoimmune disease single gut-residing species volcano plots depict splenic autoantibody-secreting cells supplementary materials included organ-specific disease provoked il-17-producing t-helper cells nod/scid recipient mice il-17 versus ifn-γ 145 mg/ml dl-dithiothreitol anti-gpi titers quantified α4β7-expressing th17 cells si-lp th17 cells gram-negative gut bacteria 16s rrna sequences si-lp cell isolation compare gene expression il17a gene expression genomic dna providing il-17r−/− mice cd3+cd4+b220− cells

Questions {❓}

• How can commensal microbes impact on the production of IL-17 by splenic T cells?
• How does SFB promote the development of joint inflammation in K/BxN mice?
• Should tetracycline treatment be used more extensively for rheumatoid arthritis?

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