
NCBI . NLM . NIH . GOV {
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Title[redir]:
Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance - PMC
Description:
Epidemiological studies suggest that statins (hydroxymethylglutaryl-CoA reductase inhibitors) could reduce the risk of Alzheimer disease. Although one possible explanation is through an effect on β-amyloid (Aβ) metabolism, its effect remains to be ...
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Keywords {🔍}
fluvastatin, brain, levels, doi, pubmed, google, scholar, fig, appctfs, app, level, mice, pmc, clearance, lrp, treatment, control, article, rab, fraction, free, protein, statins, lysosomal, group, effects, japan, degradation, analysis, reduction, study, reduced, appctf, previously, metabolism, data, buffer, microsomal, upregulation, increased, tokyo, supplemental, increase, effect, production, mgkgday, western, blot, quantification, cbl,
Topics {✒️}
protease inhibitor mixture anti-adam17/tnf-α converting enzyme tissue homogenization buffer familial ad-linked mutation brain efflux index blood-brain barrier detect full-length app insulin-degrading enzyme app c-terminal fragment liquid scintillation mixture bace inhibitor-iv reduced s-phenylglycine t-butyl ester human/mouse aβ elisa human/mouse aβ42 elisa bace inhibitor-iv anti-app c-terminal liquid chromatography hydroxymethylglutaryl-coa reductase inhibitor ice-cold ecf buffer blood vessel walls detect secreted app specific pathogen-free facilities hplc fractionation hplc apparatus warmed ecf buffer anti-amyloid precursor anti-app n-terminal publisher site pdf endogenous wild-type app-ctfs efflux process endothelial cell marker aβ elisa system hydroxymethylglutaryl-coa reductase inhibitors pmc beta search ecf buffer tissue solubilizer repeated measures anova brain β-amyloid vitro uptake assay amyloid precursor 100 μg/ml penicillin/streptomycin elisa analysis liquid scintillation counter pmc copyright notice major aβ-degrading enzymes 5 mg/kg/day fluvastatin anti-lrp1-light chain sds-page fluorography high plasma concentration anti-lrp1-heavy chain
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