
NCBI . NLM . NIH . GOV {
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Title[redir]:
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice - PMC
Description:
Mutations in the tumor-suppressor gene phosphatase and tensin homolog deleted on chromosome 10 (Pten) are associated with multiple cancers in humans, including T cell malignancies. Targeted deletion of Pten in T cells induces both a disseminated ...
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Keywords {🔍}
mice, cell, doi, cells, pten, ptenδt, figure, pubmed, google, scholar, lymphomas, notch, cmyc, data, lymphoma, expression, pmc, translocation, article, shown, tcr, autoimmunity, mutations, development, signaling, free, gene, tumors, tumor, thymocytes, analysis, lines, translocations, transformation, weeks, otiiptenδtrag, loss, thymus, thymic, rag, representative, antibodies, thymectomized, leukemia, distinct, mature, malignant, age, absence, bone,
Topics {✒️}
ot-ii/pten-δt-rag1–/– animals ot-ii/pten-δt-rag1–/– mice ot-ii/pten-δt-rag1–/– tumors ot-ii/pten-δt-rag+/+ mice ot-ii/pten-δt-rag1+/+ ot-ii/pten-δt-rag1+/ ot-ii/pten-δt-rag1–/ diseased ot-ii/pten-δt generated ptenfl/flslp76fl/fl mice ot-ii/pten-δt controls lck-cre-ptenfl/fl mice generate pten/slp76-δt mice ot-ii/pten-δt ot-ii tcr transgene anti–single-stranded dna abs permit notch1-expressing double-negative pten-δt recombination-sufficient animals cell-specific pten-deficient mice cd4-cre-ptenfl/fl gsi-treated pten-δt-tcra–/ notch1-dependent c-myc overexpression notch1-mediated c-myc overexpression pmc beta search pten-δt bone marrow ot-ii mice potent γ-secretase inhibitor pten-δt mice revealed pten-δt cell lines recombination-deficient rag1–/– background diseased pten-δt mice multi-functional genetic program cd4+cd8+ thymocytes induces regulate notch1/c-myc expression termed pten-δt mice pten-δt mice made pten-δt mice failed pten-δt mice contained serine-threonine kinase akt rag-mediated dsbs contributed mouse t-cell leukemia pten-δt mice defective diverse context-dependent outcomes pten-δt-tcra–/– mice pmc copyright notice control pten-δt mice pten-δt mice relative γ-secretase inhibitor treatment bypass anti-oncogenic checkpoints thymectomized pten-δt mice upregulate c-myc expression
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- https://scholar.google.com/scholar_lookup?journal=Cell.&title=Unrepaired%20DNA%20breaks%20in%20p53-deficient%20cells%20lead%20to%20oncogenic%20gene%20amplification%20subsequent%20to%20translocations.&author=C%20Zhu&volume=109&issue=7&publication_year=2002&pages=811-821&pmid=12110179&doi=10.1016/S0092-8674(02)00770-5&'s revenue stream
- How much profit is https://doi.org/10.1182/blood-2005-07-3013 making per month?
- What's the income of https://scholar.google.com/scholar_lookup?journal=Blood.&title=Notch1%20mutations%20are%20important%20for%20leukemic%20transformation%20in%20murine%20models%20of%20precursor-T%20leukemia/lymphoma.&author=YW%20Lin&author=RA%20Nichols&author=JJ%20Letterio&author=PD%20Aplan&volume=107&issue=6&publication_year=2006&pages=2540-2543&pmid=16282337&doi=10.1182/blood-2005-07-3013&?
- How much money does https://github.com/ncbi generate?
- Monthly income for https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
- How much profit does https://www.nlm.nih.gov/web_policies.html make?
- https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office's revenue stream
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- What's the total monthly financial gain of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal?
- How much money does https://www.nlm.nih.gov/accessibility.html make?
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- What's the financial outcome of https://www.nih.gov/?
- What's the income of https://www.hhs.gov/?
- How much does https://www.usa.gov/ gross monthly?
Analytics and Tracking {📊}
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