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Title[redir]:
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency - PMC
Description:
The Myc oncogene regulates the expression of multiple components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, Pol III, and rDNA1,2. An outstanding question is whether and how increasing the ...
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Keywords {🔍}
doi, myc, cell, protein, cells, synthesis, translation, mice, fig, pubmed, google, scholar, eμmyc, cancer, cdkp, expression, downstream, normal, eμmycl, iresdependent, analysis, capdependent, mitotic, control, pmc, ribosomal, cycle, mitosis, translational, oncogenic, progression, overexpressing, initiation, levels, cytokinesis, blymphocytes, article, show, switch, accurate, instability, growth, supplementary, activation, synchronized, increased, rates, development, nature, findings,
Topics {✒️}
cd43-pe/cd45r-b220-fitc cdk11/p58-ires dependent activity cell-cycle-dependent translational control cdk11/p58 pitslre kinase restoring cap-dependent translation eμ–myc/+ versus eμ–myc/+ multi-step process leading x-linked dyskeratosis congenita mitotically arrested b-lymphocytes undergoes cap-independent translation high-incidence spontaneous lymphoma myc hyper-activation impairs cap-dependent protein synthesis cap-dependent translation downstream suppress cap-dependent translation cd19-pe/cd3-fitc cd4-pe/cd8-fitc regulates cdk11/p58 expression decreased ires-dependent translation ires-dependent translation initiation19 ires-dependent translation underlie decreased cdk11/p58 expression retroviral cdk11/p58 cdna freshly isolated b-lymphocytes mu-myc transgenic mouse augmented cap-dependent translation endogenous ires-dependent form facilitate cap-independent translation ires-dependent translation control pmc beta search eμ–myc/+ b-lymphocytes translocations involving c-myc myc+p58 cells express cdk11/p58 ires element ires-dependent translation compared eμ–myc/+ versus wt reduced mitotic-specific expression myc-induced cell growth primary b-lymphocytes hcv-ires dependent activity eμ–myc/+ cells synchronized methionine-free dmem eμ–myc/+ transgenic mice protein synthesis rates global protein synthesis increased centrosome numbers protein kinase family ires-dependent translational switch protein synthesis downstream eμ–myc/+ mice prior
Questions {❓}
- Does the ribosome translate cancer?
- Why would an increase in cap-dependent translation downstream of Myc activation decrease IRES-dependent translation?
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