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Keywords {🔍}

cells, doi, expression, fig, ecadherin, pubmed, google, scholar, cell, cancer, sum, tumor, tumors, human, mirna, metastasis, breast, pmc, myc, βcatenin, levels, article, mycn, primary, mice, data, free, hmle, carcinoma, mirexpressing, metastatic, mammary, fold, control, observed, mrna, gene, sponge, emt, shown, genes, supplementary, increase, vegf, found, nat, microrna, information, upregulated, angiogenesis,

Topics {✒️}

mmtv-c-myc transgenic mice18 multiple tcf/lef-binding sites gsk-3β-dependent inhibitory phosphorylation ae1/ae3 anti-cytokeratin antibodies sh-ep-mycn-er cells real-time rt-pcr sonic hedgehog-driven medulloblastomas mycn/c-myc-activated tumors activate β-catenin-mediated transcription pmc beta search escape proteasome-mediated degradation27 mir-9-mediated e-cadherin suppression gsk-3β phosphorylation sites myc-binding-site recognition multi-faceted transdifferentiation program activate pro-metastatic genes22 mycn-er fusion protein modulate e-cadherin expression elevated sdf-1/cxcl12 secretion pro-angiogenic factor vegfa e-cadherin promotes metastasis inhibiting beta-catenin signaling myc/mycn-overexpressing tumors42 suppressing e-cadherin expression constitutively active β-catenin noncanonical wnt/fz signaling e-cadherin levels mediated suppressed e-cadherin expression β-catenin-dependent manner candidate metastasis-suppressing mirna weaker e-cadherin staining e-cadherin-independent roles e-cadherin expression made downregulate e-cadherin expression reduce e-cadherin expression tissue-specific expression pattern16 mycn-inducible model system human-specific vimentin staining e-cadherin repressors zeb1 conserved seed pairing e-cadherin-positive cells mir-9-induced vimentin expression mock-infected sum149 cells metastases/primary tumor weight basal β-catenin activity mir-9-expressing cells showed emt-inducing signals emanating mir-9-expressing sum149 cells e-cadherin-encoding mrna mir-9-expressing tumor cells

Questions {❓}

• Can miR-9, acting on its own, initiate the EMT program?

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