
NCBI . NLM . NIH . GOV {
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Title[redir]:
Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis - PMC
Description:
There is increasing appreciation of the important role of B cells in many autoimmune diseases and consequently, increasing interest in treating these disorders through B cell-depletion therapy with rituximab, an anti-CD20 monoclonal antibody. Yet, ...
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Keywords {🔍}
cells, plasma, mice, rituximab, doi, cell, kbxn, antigpi, igg, fig, pubmed, google, scholar, gpispecific, human, treatment, longlived, populations, hcdkg, depletion, autoabs, expression, model, serum, ascs, titers, levels, lns, total, gpi, pmc, shortlived, autoimmune, blood, bxn, population, mouse, disease, plasmablasts, weeks, intracellular, arthritic, high, staining, expressed, nlm, autoreactive, arthritis, article, titer,
Topics {✒️}
biotin-labeled goat–anti-mouse igg anti-cd138 cell-surface positivity short-lived antibody-secreting cells lymphocyte-specific cell-surface marker induce full-blown disease goat anti-mouse igg alkaline–phosphate-conjugated streptavidin h-2g7 mhc loci enzyme-linked immunosorbent spot translational mini-review series alkaline phosphatase-conjugated streptavidin cd138hi gpi-positive populations autoreactive ab-secreting cells gpi-positive plasma cells fcγ fragment-specific antibody long-lived plasma cell anti-ig kappa mab glucose-6-phosphate isomerase protective-ab titers lies short-lived plasmablasts residing long-lived plasma cells pmc beta search developed full-blown arthritis gpi-specific plasma cells anti-gpi igg titers long-lived bm pool characterize anti-gpi ascs alexafluor488 anti-brdu mab h-2g7 congenic mice organ-specific disease provoked anti-gpi iggs made anti-gpi abs disappeared gpi-positive splenic cells anti-mouse cd20 mab polyclonal gpi-cd138+ populations h-2g7 congenic animals small bone-marrow aspirations short-lived plasma cells anti-gpi igg ascs studies included anti-cd138 b-cell-directed therapies short-lived plasmablasts dominate b-cell-directed therapy prolonged igg half-life short half-life coupled anti-cd20 monoclonal antibody serum anti-gpi abs major anti-gpi ascs splenic gpi-cd138+ populations autoab-producing plasma cells
Questions {❓}
- B cell depletion: A novel therapy for autoimmune diabetes?
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