
NCBI . NLM . NIH . GOV {
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Title[redir]:
EARLY T-CELL PRECURSOR LEUKEMIA: A SUBTYPE OF VERY HIGH-RISK ACUTE LYMPHOBLASTIC LEUKEMIA IDENTIFIED IN TWO INDEPENDENT COHORTS - PMC
Description:
Approximately one-fifth of children with acute T-lymphoblastic leukemia (T-ALL) succumb to the disease, suggesting unrecognized biologic heterogeneity that may contribute to drug resistance. We hypothesized that T-ALL originating from early T-cell ...
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Keywords {๐}
patients, expression, cases, doi, tall, etpall, google, scholar, gene, etp, jude, pubmed, leukemia, supplementary, typical, acute, analysis, lymphoblastic, aieop, data, tcell, mrd, table, fig, study, cell, blood, leukemic, diagnosis, remission, therapy, outcome, cohort, features, cells, clinical, years, versus, childhood, prognostic, treatment, set, early, genes, expressed, relapse, myeloid, pmc, studied, identify,
Topics {โ๏ธ}
t-cell-lineage developmental programme acute t-lymphoblastic leukemia independent-validation population consisted hepatosplenic t-cell lymphoma early t-cell precursors activating flt3 mutations cox proportional-hazards model acute lymphoblastic leukaemia pmc beta search recognized high-risk forms lymphoid-cell directed therapy acute lymphoblastic leukemia childhood t-cell malignancies lymphoid cell-directed chemotherapy stem-cell/myeloid markers risk-directed continuation treatment retain stem cell etp-related gene profile t-lineage leukemic blasts patients received remission-induction hematopoietic stem cells event-free survival ๏ฟฝmixed-lineage leukemiaโ erythroid lineage potential national cancer institute myeloid cell differentiation stem cell markers minimal residual disease full immunophenotypic profile t-cell receptor genome-wide analysis polymerase chain reaction tcr gamma/delta gene expression profiling lacked sufficient material dna copy abnormalities natural killer cell oncogenic transcription factors high leukocyte count transcription factor levels myeloid developmental potential mll gene rearrangement strong prognostic factor proportional hazards model cell marker profile t-cell markers rearranged tcr gene tcr gene rearrangementc gene expression profiles earliest thymic progenitors
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