
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Parameters for Establishing Humanized Mouse Models to Study Human Immunity: Analysis of Human Hematopoietic Stem Cell Engraftment in Three Immunodeficient Strains of Mice Bearing the IL2rγnull Mutation - PMC
Description:
“Humanized” mouse models created by engraftment of immunodeficient mice with human hematolymphoid cells or tissues are an emerging technology with broad appeal across multiple biomedical disciplines. However, investigators wishing to utilize ...
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Keywords {🔍}
mice, human, cells, engraftment, ilrγnull, doi, hsc, cell, blood, newborn, strains, pubmed, google, scholar, nodscid, immunodeficient, adult, balbcragnull, injection, engrafted, compared, strain, levels, mouse, development, immune, nod, figure, hematopoietic, peripheral, nodragnull, spleen, pmc, cord, higher, stem, scid, similar, shultz, ragnull, humanized, models, multiple, injected, thymic, immunity, greiner, article, data, system,
Topics {✒️}
β2-microglobulin-deficient nod-scid mice rag2/gammac double-knockout mice newborn nod/scid/beta2-microglobulin adult [termed hu-src-scid c57bl/6j-scid bg mice balb/c-rag1null il2rγnull mice balb/c-rag2null il2rγnull stocks balb/c-rag2null il2rγnull strain nod/ltsz-scid/scid mice balb/c-rag1null il2rγnull stock b-17-scid/bg immunodeficient mice human-hemato-lymphoid-system mice interleukin-2 receptor γ-chain balb/c-rag1null il2rγnull 1 balb/c-rag1null il2rγnull balb/c-rag2null il2rγnull balb/c-scid bg multi-lineage differentiation markers termed hu-pbl-scid c57bl/6j-scid mice nod/ltsz-scid il2rγnull nod/ltsz -scid il2rγnull il-2rγ-chain deficient rat anti-mouse fcr11b balb/c-il2rγnull strain balb/c-rag1−/−gammac−/− nod/shi-scid il2rγnull sulfamethoxazole-trimethoprim medicated water balb/c-rag1nullil2rγnull mice 49 balb/c-rag1nullil2rγnull mice rag recombination-activating gene fetal [termed scid-hu multi-lineage cell populations nod/ltsz-rag1nullprf1null mice balb/c-rag1null strain long life span pre-existing immunologic abnormalities nod/ltsz-rag1null mice newborn nod-scid il2rγnull canninga-van dijk mr nod-scid il2rγnull mice pmc beta search nod-rag1null il2rγnull mice hu-src-scid model balb/c-rag1nullil2rγnull strains b-17-scid/scid mice hla-a2-restricted cd8 b2mnull nod/scid mice hu-pbl-scid model cell-depleted cord blood
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