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Title[redir]:
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice - PMC
Description:
The Cu-binding β-amyloid precursor protein (APP), and the amyloid Aβ peptide have been proposed to play a role in physiological metal regulation. There is accumulating evidence of an unbalanced Cu homeostasis with a causative or diagnostic link to ...
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Keywords {🔍}
mice, app, treatment, pubmed, google, scholar, doi, levels, brain, sod, activity, plaque, amyloid, months, fig, transgenic, effect, water, age, weight, multhaup, biol, reduced, masters, chem, pmc, nontransgenic, vehicle, group, beyreuther, influence, drinking, significant, littermate, period, male, overexpression, mouse, increase, effects, load, monthold, protein, observed, increased, treated, groups, analysis, rate, life,
Topics {✒️}
6-trimethyl-2-vinylpyridinium trifluoromethane-sulfonate α-secretory app–cu complexes cu-induced lower aβ40 pmc beta search formic acid-dissolved aβ cu-deficient sucrose diet sex-matched littermate controls sucrose-supplemented drinking water short-term treatment cohort received cu-supplemented sucrose formic acid-soluble aβ40 protein-blotting analysis showed cu-supplemented drinking water short-term treatment period lowering pbs-soluble aβ40 quantitative icp-ms measurements disturbed metal-ion homeostasis long-term treatment period long-term treatment group formic acid-soluble app cu-binding ectodomain amyloid precursor protein license information pmcid n-terminal domain α-secretory forms n-terminal cubds cu-binding site publisher site pdf cu-treated app23 mice long-term exposure 4-μm-thick paraffin sections short-term treatment rodent breeding diet receiving vehicle solution cu-supplemented sucrose littermate nontransgenic controls nontransgenic littermate controls long-term treatment human app carrying human app leads α-secretase close cu-binding domain 64 units/mg protein 76 units/mg protein 69 units/mg protein units/mg protein cu-supplemented carbohydrate cu-nitrilotriacetic acid predominant soluble species taking video frames
Questions {❓}
- Which mechanism is responsible for Aβ reduction in APP23 mice?
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