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Keywords {🔍}

htt, phosphorylation, fig, doi, pubmed, google, scholar, ikk, cells, protein, httexp, phosphorylated, levels, mutant, ikkβ, cell, clearance, pmc, huntingtin, polyq, degradation, lysosome, article, control, proteasome, lampa, free, analysis, sta, disease, nuclear, species, acetylation, reduced, unexpanded, steffan, localization, western, min, antibodies, repeat, hsc, proteins, neurons, toxicity, antihtt, lysosomal, modified, expanded, mab,

Topics {✒️}

map kinase/erk-dependent mechanism org/cgi/content/full/jcb p-human-ha-lamp-2a anti–rat lamp-2a igp96 anti–α-tubulin clone b-5-1-2 human ha-tagged lamp-2a anti–rat/mouse lamp-2a qtax-based tag-team strategy s13-phosphorylated full-length htt ni-nta magnetic nickel full-length endogenous htt phosphorylated endogenous full-length plan-apochromat 63x objective homeodomain-interacting protein kinase-2 nuclear factor-kappab contributes particle-mediated gene transfer detect flag-tagged ikk-β goat anti–rabbit hrp pmc beta search affinity-purified polyclonal antiserum downstream post-translational modifications goat anti–mouse hrp pmc copyright notice esi-ms/ms spectra lamp-2a–dependent mechanism phosphorylate full-length creates phosphodegrons/binding motifs standard ikk-activating cytokines htt post-translational modifications phosphomimetic 97qp-dd-gfp htt post-translational modification 250-µm-thick coronal slices hdhq111/q111-expressing cells mutant n-terminal fragment serum-free medium expanded 97qp-dd-gfp kinase-gamma/nf-kappa phosphorylation-activated ikk-mediated clearance applied biosystems/pe sciex post-translational modifications extend background-corrected pixel intensities anti-htt em48 mab5374 lamp-2a levels decline phosphomimetic 97qp-dd httex1p detect ha-hlamp-2a wild-type sthdhq7/hdhq7 regulate post-translational modification full-length acetylated full-length protein 97qp-dd-gfp plasmids

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