
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The 26 S Proteasome: From Basic Mechanisms to Drug Targeting - PMC
Description:
The regulated degradation of proteins within eukaryotes and bacterial cells is catalyzed primarily by large multimeric proteases in ATP-dependent manner. In eukaryotes, the 26 S proteasome is essential for the rapid destruction of key regulatory ...
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Custom-built
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
pubmed, google, scholar, doi, proteasome, cell, biol, ubiquitin, proteins, article, inhibitors, pmc, particle, rpn, activity, subunits, complex, finley, degradation, cells, polyubiquitin, nat, substrates, substrate, mol, free, drug, enzyme, active, chem, protein, residue, lysine, rev, nlm, regulatory, apoptosis, target, residues, proteasomal, nfκb, fig, bortezomib, inducing, chains, ring, chain, data, nterminal, bind,
Topics {✒️}
endoplasmic reticulum nedd8-activating enzyme mln4924 skp2/cullin/f-box protein discovered ubiquitin/polyubiquitin-binding protein weak protein-protein interactions endoribonuclease/kinase ire1α c-terminal glycine define α-subunit n-terminal domains activated c-terminal glycine inducing jnk-mediated apoptosis reconstituted cell-free system n-terminal threonine residue selective response c-terminal glycine multiple ubiquitin moieties n-terminal domains ubiquitin-binding proteasomal subunit myeloma cell proliferation n-terminal domain α1–7β1–7β1–7α1–7 spontaneous chaperone-assisted formation n-terminal propeptides heterodimeric p50-p65 regulator e1 catalytic site activate jnk claso-lactacystin β-lactone myeloma cells unfolded polypeptides ups drug target pmc beta search e2 active-site cysteine pmc copyright notice malignant ig-secreting cells nf-κb transcription regulator transcription regulator nf-κb nf-κb activation pathway receptor-interacting protein e6-ap carboxyl terminus inhibiting nf-κb activation precursor protein p105 e2 enzyme conserved protein complex e3 enzyme cullin-ring e3 complexes substrate-linked polyubiquitin chain resulting half-proteasomes dimerize multiple monoubiquitinations e2/e3 enzymes unfolded multiple mechanisms
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