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Title[redir]:
tRNA over-expression in breast cancer and functional consequences - PMC
Description:
Increased proliferation and elevated levels of protein synthesis are characteristics of transformed and tumor cells. Though components of the translation machinery are often misregulated in cancers, what role tRNA plays in cancer cells has not been ...
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Keywords {π}
trna, breast, cell, genes, cancer, expression, trnas, rna, doi, lines, codon, ligation, total, usage, relative, overexpression, levels, human, figure, google, scholar, samples, pubmed, isoacceptors, data, cells, tumor, analysis, housekeeping, mcfa, median, fold, cancerrelated, versus, chemical, level, translation, results, microarray, probes, pmc, association, differences, amino, phosphorothioate, mrna, method, array, noncancerderived, nuclear,
Topics {βοΈ}
cancer-related versus cancer-related cancer-related versus house-keeping full-length trna templates [pubmed] [google scholar] cell line-specific genes cell-line specific genes pmc beta search cancer-derived cell lines cancer-derived cell lines phosphorothioate-iodide autoligation chemistry identify cancer-related genes methods cell lines cy5 fluorophore pre-attached nuclear-encoded trnas carrying mitochondrial-encoded trna levels identify house-keeping genes specific cancer-related genes accession number e-tabm-157 human mitochondrial-encoded trnas liver-specific genes approach potentiating post-translational regulation high-throughput genomic technology mitochondrial-encoded trnas increase fluorescent-labeled ligation products trnas carrying polar human nuclear-encoded trnas detecting single-nucleotide differences cold spring harbor publisher site pdf averaged cy5/cy3 ratio cell line-specific detect single-base differences cy5-labeled total rna systematic genome-wide studies cognate amino acids genome-wide results show low-abundant trna levels trna-based codon usage nuclear-encoded trnas increase erβ/her2β tumor samples er+/her2β tumor samples trna-codon usage association line-specific genes nucleic acids res breast cell lines study tissue-specific expression amino acids serine nucleic acids research supplementary materials included normal breast tissue
Questions {β}
- Does the ribosome translate cancer?
- Is the codon usage of cell-line specific genes related to the over-expression patterns of nuclear-encoded tRNAs in breast cancer cells?
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