
NCBI . NLM . NIH . GOV {
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Title[redir]:
Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions - PMC
Description:
Glutathione peroxidase 4 (Gpx4) is an essential antioxidant enzyme having multiple functions. A long form Gpx4 protein and a short form Gpx4 protein, which are distinguishable by the presence or lack of a mitochondrial signal peptide at the N ...
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Keywords {๐}
mice, gpx, protein, sgpx, lgpx, tgsgpxgpx, gene, tissues, levels, mitochondria, sperm, mitochondrial, tgsgpx, tglgpx, doi, pubmed, google, scholar, total, data, fig, liver, shown, male, form, apoptosis, biol, somatic, results, transcripts, min, transgenic, mutation, testes, study, rescue, gpxnull, fertility, nuclei, fractions, compared, controls, embryonic, determined, showed, lethal, phenotype, tissue, found, expressed,
Topics {โ๏ธ}
site-directed mutagenesis technique n-terminal mitochondrial signal site-directed mutagenesis strategy pathogen-free barrier conditions voltage-dependent anion channel paraffin-embedded tissue sections pmc beta search pcr-based genotyping protocol pmc copyright notice oxidative stress-induced apoptosis phosphate-buffered saline supplemented molecular research center mouse gpx4-null mutation generate pcr-wtgpx4 construct transgenic mice overexpressing institutional animal care compared diquat-induced apoptosis san antonio gpx4-null mice rescued transcription initiation sites phosphate-buffered saline wild-type mice experimental procedures generation lower site predominantly publisher site pdf gpx4-null mice die license information pmcid nuclear form nuclease-free water direct evidence showing health grants p01ag19316 long form gpx4 short form gpx4 mitochondrial signal peptide induced cerebral apoptosis atg start codon mutation strategy affects mitochondrial signaling peptide standard pcr profile united states government si-eun yoo ยง repairs lipid peroxidation hydroperoxy fatty acids repairing lipid peroxidation nsii restriction enzymes fed ad libitum relative copy numbers atpase ฮฒ subunit cis-regulatory elements diquat-induced apoptosis
Questions {โ}
- How does sGpx4 protein enter mitochondria without a mitochondrial leader sequence?
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