
NCBI . NLM . NIH . GOV {
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Title[redir]:
Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway - PMC
Description:
Amyloid β-peptide (Aβ) has a central role in the pathogenesis of Alzheimer’s disease (AD). Cellular cholesterol homeostasis regulates endoproteolytic generation of Aβ from the amyloid precursor protein (APP). Previous studies have identified ...
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Keywords {🔍}
app, cells, doi, acat, pubmed, google, scholar, protein, min, cell, fig, inhibition, mature, treated, levels, amyloid, pathway, maturation, secretory, mice, immature, early, reduced, retention, holoprotein, treatment, pmc, precursor, alzheimers, data, usa, cholesterol, generation, proteins, results, cptreated, trafficking, disease, inhibitors, shown, appc, western, vehicle, biol, article, appim, content, activity, brain, free,
Topics {✒️}
β-secretase-generated c-terminal fragments live-cell-imaging technique utilizing β-secretase-mediated proteolytic processing chop [ccaat/enhancer-binding protein methionine/cysteine-free medium 99-aa c-terminal fragment 83-aa c-terminal fragment beta-site specific intrabodies secretase-mediated proteolytic processing sorla/lr11 regulates processing pmc beta search wild-type app751–v5 c-terminal dilysine motif 2-photon live-cell imaging γ-secretase-mediated processing 35-mm glass-bottom dishes app c-terminal fragments specific stress-sensor systems early upr-induced gene amyloid beta-peptide generation disease beta-amyloid peptides wild-type mice treated construct encoding app695-pagfp gamma-secretase-substrate receptor live-cell imaging data γ-secretase component levels triton-nonidet p-40 buffer effective disease-modifying therapies intracellular retention half-times n-terminally truncated form presenilin-dependent γ-secretase acat-defective ac29 cells live-cell imaging studies app751-v5-kkaa results cell-surface metalloproteases adam10 plasmid encoding dsred2-er proteasome inhibitor-dependent manner amyloid precursor protein β-secretase cleavage occurs c-terminal app antibodies app c-terminal antibodies acat inhibitor-treated mice α-secretase cleavage occurs sterol-responsive er retention acat inhibitor-treated cells acat-inhibitor treated cells c-terminal fragments decreased steady-state levels chaperone bip/grp78 binds ci-1011-treated happ mice
Questions {❓}
- What is the mechanism connecting reduced ACAT activity to enhanced ERAD of APP?
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