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Title[redir]:
Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice - PMC
Description:
Diabetic nephropathy is the leading cause of chronic renal failure. Myofibroblasts play a major role in the synthesis and secretion of extracellular matrix in diabetic renal fibrosis. Increasing evidence suggests that endothelial cells may undergo ...
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Keywords {🔍}
cells, doi, endothelial, renal, mice, tgfβ, pubmed, google, scholar, diabetic, endomt, mouse, fibrosis, myofibroblasts, figure, development, αsma, interstitial, tiecreloxpegfp, diabetes, cell, confocal, expression, stzinduced, pmc, microscopy, egfpαsma, kidneys, demonstrated, egfp, article, month, number, smad, type, ngml, transition, nephropathy, mmecs, early, sis, analysis, free, line, kidney, versus, contributes, role, progression, signaling,
Topics {✒️}
tgf-β1-induced epithelial-myofibroblast transition egfp+/α-sma+ double-labeled cells tgf-β/smad2/3 signaling pathways α-sma/eyfp mouse line tgf-β1/smad3 signaling protects α-sma/glyceraldehyde-3-phosphate dehydrogenase tgf-β1/smad signaling plays mouse anti-α-sma conjugated inhibit tgf-β-induced endomt inhibit tgf-β1-induced endomt abrogates tgf-β1-induced endomt α-sma/eyfp mouse kidneys tgf-β1/smad3 signaling pathway α-sma+/egfp−/cd31− cell α-sma+/egfp+/cd31+ cells α-sma+/egfp+/cd31− cells transforming growth factor-β1 gittenberger-de groot ac mouse glyceraldehyde-3-phosphate dehydrogenase 5 ng/ml tgf-β1 1 ng/ml tgf-β1 egfp+/α-sma+ cells/mm2 tgf-β1 induces endomt rat anti-cd31 conjugated cd31/glyceraldehyde-3-phosphate dehydrogenase streptozotocin-induced diabetic glomerulopathy end-stage renal disease smooth muscle actin recombinant human tgf-β1 egfp+/α-sma+ cell pmc beta search tgf-β1-induced endomt tgf-β type ii α-sma promoter/enhancer α-sma/eyfp mice fluorescence-activated cell sorting endothelial cell-lineage analysis positive/α-sma+ cells α-sma-positive cells undergo endothelial-myofibroblast transition pmc copyright notice egfp+/α-sma+ cells select cd31+/eyfp− cells endothelial-myofibroblast transition occurs loxp-egfp mouse kidneys rat anti-ve-cadherin cd31+/eyfp− endothelial cells smad3-null mice demonstrates renal cd31+/eyfp− cells rat anti-cd31 allophycocyanin
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