
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis - PMC
Description:
In rheumatoid arthritis (RA), dysfunctional T cells sustain chronic inflammatory immune responses in the synovium. Even unprimed T cells are under excessive replication pressure, suggesting an intrinsic defect in T cell regeneration. In naive CD4 ...
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Keywords {๐}
cells, dna, atm, cell, patients, fig, repair, damage, mre, control, levels, naive, pubmed, google, scholar, doi, rad, controls, nbs, apoptosis, protein, transfected, transcript, expression, radiation, experiments, complex, quantified, shown, sem, components, rheumatoid, data, defect, independent, transcription, min, pmc, transfection, cdcdro, means, breaks, overexpression, response, tms, increased, western, fluorescence, higher, stress,
Topics {โ๏ธ}
org/cgi/content/full/jem real-time rt-pcr analysis sequence-specific dna cleavage antigen-nonspecific homeostatic proliferation dna double-strand breaks pmc beta search human leukemia ccrf-cem entire dna breakage-sensing t-cell-targeted therapies fe2+-mediated fenton reactions pmc copyright notice uvc-induced dna damage disease-modifying antirheumatic drugs cells remained free provide negative-feedback inhibition radiation-induced dna breaks nijmegen breakage syndrome cell divisionโinduced shortening atm-specific sirna oligonucleotides publisher site pdf ensure full lysis single-strand breaks freshly isolated cd4+cd45roโ double-strand break ataxia telangiectasia-mutated kinase dna strand breaks substantially lower amounts dna repair capabilities chronic inflammation appears excluding rna instability 18s ribosomal rna t-cell development repairing dna breaks dna damage mechanisms chronic antigenic stimulation age-inappropriate telomeric shortening defect equally affects dna damage sensing dna damage-sensing license information pmcid reached levels comparable horizontal electrophoresis chamber machinery include mre11 blue lines represent similar discrepancy exists increased proliferative turnover dna damage load molecular pathway underlying restoring apoptotic resistance cell proliferation functions
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Analytics and Tracking {๐}
- Google Analytics
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- jQuery
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Emails and Hosting {โ๏ธ}
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