
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Human Guanylate Binding Proteins Potentiate the Anti-Chlamydia Effects of Interferon-γ - PMC
Description:
Chlamydiae are obligate intracellular pathogens that are sensitive to pro-inflammatory cytokine interferon-γ. IFN-γ-inducible murine p47 GTPases have been demonstrated to function in resistance to chlamydia infection in vivo and in vitro. Because ...
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Keywords {🔍}
hgbp, doi, ifnγ, cells, pubmed, google, scholar, growth, chlamydia, chlamydial, trachomatis, inclusion, hgbps, inclusions, antichlamydial, pmc, inhibition, serovar, infection, human, figure, article, function, cell, proteins, gtpases, overexpression, gbp, expression, hela, free, gtpase, induction, data, effects, domain, treatment, cytotoxin, ctr, resistance, activity, protein, binding, gene, genes, transfection, ngml, murine, induced, mutant,
Topics {✒️}
n-terminal hemagglutinin tag encode ifn-γ-inducible homologues chicken guanylate-binding protein ifn-γ-mediated downstream processes ifn-γ-induced genes includes gamma-interferon-stimulated activity ifn-gamma-mediated antimicrobial response guanylate-binding protein-1 expression pro-inflammatory cytokine interferon-γ ha-tagged full-length hgbp2 phospho-enol-pyruvate carboxykinase ifn-γ-induced gene encoding ifn-gamma-inducible cofactor interferon-inducible gbp1 gene pmc beta search require perforin-mediated cytolysis ifn-γ visibly attenuated ifn-γ strongly implicates gamma-interferon-mediated inhibition gamma interferon-mediated inhibition ifn-γ-inducible proteins interferon-alpha prevents apoptosis ifn-γ-mediated suppression ifn-gamma-mediated inhibition full-length cytotoxin genes full-length cytotoxin gene primary anti-chlamydial effector guanylate binding proteins potential anti-chlamydial activity c-terminal helical domain myc-gbp-1 expression construct guanylate binding activity pcmv-myc gbp-1 construct ifn-γ-induced genes ifn-γ-mediated elimination cells overexpressing myc-hgbp1 discussion interferon-γ delayed-type hypersensitivity ifn-γ-mediated inhibition potent anti-chlamydial activity similar ifn-γ responsiveness ifn-γ-mediated clearance chlamydia species/strains harboring license information pmcid ifn-γ hela cells publisher site pdf hgbps link ifn-γ 5 ng/ml ifn-γ 05 ng/ml ifn-γ p47 gtpase-based resistance
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