
NCBI . NLM . NIH . GOV {
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Title[redir]:
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization - PMC
Description:
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non–self-cytosolic RNA and dsDNA. ERIS ...
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Keywords {🔍}
eris, cells, doi, fig, protein, ifn, transfected, type, pubmed, google, scholar, dimerization, cell, innate, immune, membrane, expression, induction, production, antibody, activation, data, nature, signaling, plasmid, domains, localization, found, signal, reporter, antiha, buffer, response, rna, dsdna, infection, showed, results, ifnβ, haeris, pmc, immunity, antiviral, vsv, min, rir, induced, assay, analyzed, microscopy,
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org/cgi/content/full/0900850106/dcsupplemental er-retention/retrieval signal antagonized double-stranded b-form dna ifn-β promoter–luc construct virus-triggered ifn-beta signaling dexd/h-box helicases rig ifn-β–luc reporter plasmid er retention/retrieval signal adaptor molecule-1-mediated nf-kappab pmc beta search activate ifn-β promoter eris-induced ifn-β activation coumermycin-induced eris-gyrb dimerization adaptor inducing ifn-beta recombinant human ifn-β intracellular membrane-coated compartments tk-renilla reporter gene myd88-independent lps signaling ifn-β–luc plasmid interferon-sensitive response element coumermycin-induced eris-gyrase flag-tagged mutant lacking pre-protrypsin leader sequence regulate ifn-β production adaptor triggering rig-i regulated ifn-β expression er retention/retrieval myd88-independent tir signalling adaptive immune responses double-stranded oligonucleotides ifn-β induction stimulated full-length eris eris-gyrb fusion protein double-stranded rna ifn-β promoter er retention signal toll/interleukin-1 receptor domain supporting information online er retention signals supplementary materials included ifn-β–luc signal peptide deleted antiviral immune response flag-tagged expression plasmids innate immune response reverse transcription system tank-binding kinase-1 innate immune challenges innate immune challenge site-directed mutagenesis
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