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Title[redir]:
MitochondriaโA Nexus for Aging, Calorie Restriction, and Sirtuins? - PMC
Description:
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in ...
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Keywords {๐}
doi, mitochondrial, google, scholar, pubmed, mitochondria, increase, electron, sirt, pmc, aging, ros, transport, chain, article, free, activity, nature, science, energy, respiration, production, sirtuins, effects, biogenesis, guarente, mice, life, span, complex, electrons, restriction, cells, figure, number, function, damaged, yeast, autophagy, cell, calorie, important, proteins, damage, fat, nlm, rate, muscle, observed, recent,
Topics {โ๏ธ}
amp-dependent protein kinase cytosolic ubiquitin/proteasome system pmc beta search [google scholar] yang inducing fatty-acid oxidation nad/nadh ratio include cytochrome b-c1 complex nad/nadh ratio due extends life span extend life span longer life span long life span ad libitum feeding cytochrome c1 prevents antioxidant enzyme catalase upregulates mitochondrial function nuclear nad pool improved rotarod performance rodgers jt decreased blood glucose metabolically inactive tissue publisher site pdf pmc disclaimer nad/nadh ratio acyl-coa dehydrogenase recent paper showed sirt1 protein levels long-term cr mitochondrial protein tfam electron transport prevented terminal electron acceptor electron transport chains united states government license information pmcid fruit fly drosophila autoregulatory feedback loop month human trial steady-state condition placing great emphasis souza-pinto nc reactive oxygen species ad libitum case severe tissue damage recent evidence suggests electron transport chain oxygen reperfusion resulting resemble premature aging damage macromolecules progressively earliest molecular theory play important roles
Questions {โ}
- But what about the increase in mitochondrial biogenesis observed during CR?
- First, can the autophagic machinery selectively recognize and destroy damaged mitochondria?
- How might the biogenesis of mitochondria, described above, relate to the reduction of ROS observed during CR?
- MitochondriaโA Nexus for Aging, Calorie Restriction, and Sirtuins?
- Why Is Activation of Mitochondria Good?
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