
NCBI . NLM . NIH . GOV {
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Title[redir]:
Prolactin–Growth Factor Crosstalk Reduces Mammary Estrogen Responsiveness Despite Elevated ERα Expression - PMC
Description:
Most breast cancers that occur in women express estrogen receptor α (ERα). However, a large subset of these cancers either does not initially respond to anti-estrogen therapy or develops resistance to such treatment modalities. One postulated ...
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Keywords {🔍}
doi, females, erα, google, scholar, pubmed, prl, estrogen, tgfα, cancer, expression, mammary, cells, glands, bitransgenic, breast, tumors, figure, receptor, nrltgfα, levels, nrlprltgfα, proliferation, epithelial, treatment, transgenic, mice, tumor, prolactin, progesterone, genotypes, compared, development, growth, reduced, latency, akt, ductal, gland, ovariectomized, pmc, normal, increased, steroid, nrlprl, ovx, factor, article, phosphorylation, cell,
Topics {✒️}
rose-hellekant ta phosphatidylinositol 3-kinase/akt/mammalian target age-matched nrl-tgfα females sham-treated nrl-tgfα females ovariectomized nrl-prl/tgfα females bitransgenic nrl-prl/tgfα females nrl-prl/tgfα bitransgenic females tgn[nrl-tgfa]25eps bitransgenic ovx-e2-treated females bitransgenic nrl-prl/tgfα animals ovx-e2-treated nrl-prl nrl-prl females demonstrated transforming growth factor-alpha transforming growth-factor-alpha tgn[nrl-prl]23eps ovariectomized nrl-tgfα females pmc copyright notice mann-whitney post test modulating promoter-binding proteins nrl-prl/tgfα glands compared pmc beta search serum-free media e2-treated ovariectomized females age-matched nrl-prl distinct e2-driven pathways permitting autocrine/paracrine action nrl-prl female controls nrl-prl/tgfα females growth factor-initiated signals ovariectomized nrl-prl/tgfα estrogen-insensitive nrl promoter30 upstate-cell signaling solutions tgf-alpha-induced activation grant number k01-rr021858 bitransgenic nrl-prl/tgfα developed epithelial hyperplasias focal epithelial hyperplasias e2-activated ap-1 sites prolactin induces erα-positive sham-treated nontransgenic females o'malley bw nrl-prl/tgfα glands singly nrl-tgfα glands total erα-expressing cells tgfα-induced tumor morphology worse long-term prognosis demonstrated dilated ducts 6-diamidino-2-phenylindole-stained nuclei single transgenic females demonstrated enhanced levels
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