
NCBI . NLM . NIH . GOV {
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Title[redir]:
Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis - PMC
Description:
Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired drug ...
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Keywords {🔍}
cells, bso, mcfa, apoptosis, doi, estradiol, cancer, glutathione, cell, bcl, pubmed, google, scholar, treatment, breast, control, compared, levels, effect, apoptotic, estrogen, mcf, figure, mitochondrial, treated, growth, protein, usa, gsh, jnk, group, death, sulfoximine, combination, data, performed, tumor, days, resistant, expression, resistance, estradiolinduced, pathway, buthionine, staining, shown, experiments, human, significantly, cytochrome,
Topics {✒️}
c-jun n-terminal kinase c-jun nh2-terminal kinase n-2-hydroxyethylpiperazine-n'-2-ethanesulfonic acid pan-caspase inhibitor z-vad estrogen-free rpmi media n-terminal activation domain jnk substrate phospho-c-jun c-jun/jnk signaling pathway stress-activated protein kinase heat stress-induced perturbations water-soluble tripeptide composed pmc beta search thiol-mediated redox regulation real-time quantitative pcr quantitative real-time pcr references herold ci transcription factor c-jun mitogen-activated protein kinases anti-fluorescein antibody conjugated cellular oxidation-reduction potential death receptors fasr/fasl bso-mediated estradiol-induced apoptosis ncr-foxn1nu athymic mice selective estrogen-receptor modulators long-term estrogen deprivation o'dwyer pj c-jun/jnk pathway metastatic breast cancer low-dose estrogen therapy paraffin-embedded tumor sections cross-sectional tumor area supplementary materials included estrogen-free media competing interests advanced breast cancer license information pmcid significant time-dependent decrease intravenous l-buthionine sulfoximine annexin v-fluorescein isothiocyanate annexin v-positive cells wild-type mcf-7 cells anti-cox iv antibody bcl-xl inhibit apoptosis positive breast cancer publisher site pdf bcl-xl protein levels annexin v-propidium iodide clonal cell line phospho-bcl-2 protein levels phosphorylated c-jun
Questions {❓}
- Karnofsky lecture: the paradoxical actions of estrogen in breast cancer – survival or death?
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