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Title[redir]:
SUMO-Mediated Inhibition of Glucocorticoid Receptor Synergistic Activity Depends on Stable Assembly at the Promoter But Not on DAXX - PMC
Description:
Multiple transcription factors, including members of the nuclear receptor family, harbor one or more copies of a short regulatory motif that limits synergistic transactivation in a context-dependent manner. These synergy control (SC) motifs exert ...
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Keywords {🔍}
sumo, motifs, doi, pubmed, google, scholar, sumoylation, activity, receptor, dbd, control, cells, synergy, dna, function, daxx, expression, binding, motif, data, modification, fig, gal, transcriptional, promoter, dimer, mutant, effects, sites, tat, pmc, biol, glucocorticoid, article, inhibitory, gene, stable, multiple, functional, free, inhibition, response, interface, analysis, regions, cell, domain, independent, effect, shown,
Topics {✒️}
mouse anti-β-actin ac-15 sumo-rangap1-ubc9-nup358 complex references iñiguez-lluhí ja ubiquitin-conjugating enzyme ubc9 strongest ha-immunoreactive species estrogen-related receptor α1 dead-box protein dp103 pmc beta search protein-protein interactions involving genome-wide rnai screen short hydrophobic/acidic sequences noncanonical half-site spacing recent large-scale survey phenylethanolamine n-methyltransferase gene sumo-ylation-deficient form conserved di-glycine motif sumo-ylation-deficient forms dimer interface-dependent interactions forming high-affinity dimers sc motif-deficient forms van buul-offers sc agonist-bound nuclear receptors high-affinity dna binding intact ligand-binding domain small ubiquitin-related modifier-1 control pcmvβ-gal plasmid prsvβ-gal control plasmid positive-acting histone modifications rous sarcoma virus phosphorylation-dependent sumo modification n-terminal [activation function zinc-finger mutant calcium-phosphate transfection protocol modifier-dependent transcriptional repression sds-page sample buffer full-length receptor contributes sumo-binding protein daxx promoter-bearing canonical sites sc motif sumo-ylation sumo-mediated synergy control intact dna-binding domain results dna-dependent dimerization c-terminal domain essential sumo-ylation-dependent inhibition sumoylation-dependent synergy control ligand-independent constitutive activator gene-specific transcriptional regulation tfiid promoter-binding activity sumo-modified gr species sumo-dependent gr regulation
Questions {❓}
- Li Q, Johnston SA 2001 Are all DNA binding and transcription regulation by an activator physiologically relevant?
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