
NCBI . NLM . NIH . GOV {
}
Title[redir]:
E2A proteins promote development of lymphoid-primed multipotent progenitors - PMC
Description:
The first lymphoid restricted progeny of HSCs are lymphoid-primed multipotent progenitors (LMPPs), which have little erythro-myeloid potential but retain lymphoid and granulocyte/macrophage differentiation capacity. Despite recent advances in the ...
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Keywords {๐}
doi, lmpps, cells, pubmed, google, scholar, genes, cell, expression, proteins, lymphoid, figure, mice, development, hscs, progenitors, number, pmc, potential, gene, transcription, flt, article, differentiation, required, mpps, free, kee, lineage, reduced, multipotent, notch, murre, expressed, data, fate, specification, role, ccr, lsks, factors, hematopoietic, stem, ikaros, found, immunol, proliferation, lymphocyte, lmpp, subset,
Topics {โ๏ธ}
basic helix-loop-helix helix-loop-helix gene e2a linโc-kitlowil-7rฮฑ+sca-1+flt3+ helix-loop-helix proteins alpha/beta t-cell development amplify multi-exon sequences serine/threonine kinases 3pk greater erythro-myeloid output pmc beta search magnetic-activated cell separation lymphoid-primed multipotent progenitors lymphoid primed-multipotent progenitors lineageโsca-1+c-kithigh e-protein activity provided early t-lymphocyte progenitors lymphoid-restricted multipotent progenitors c-kitlowil-7rฮฑ+ subpopulation earliest lymphoid-primed progeny flt3-expressing multipotent progenitors early t-lymphocyte development 50 ng/ml flt3-ligand produce sufficient numbers retroviral supernatants produced transcription start site granulocyte/macrophage differentiation capacity functional bm-derived lmpps erythro-myeloid progenitors haematopoietic cell-fate decisions supplementary materials included b-cell lineage commitment erythro-myeloid potential media lacking serum erythro-myeloid specficiation basic mechanisms dissociating lympho-myeloid fate prevent t-cell development multipotent hematopoietic progenitors robanus maandag ec caspase-2-dependent apoptosis lymphoid transcription factors single progenitor cell transcription factor regulation lymphoid progenitor potential license information pmcid megakaryocyte/erythrocyte progenitor graph summarizes results lai ay transcription factors e12 transcription start sites methycellulose based assay
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