
NCBI . NLM . NIH . GOV {
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Title[redir]:
Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target - PMC
Description:
Cyclin D1 (CyD1) is a pivotal cell cycle-regulatory molecule and a well-studied therapeutic target for cancer. Although CyD1 is also strongly up-regulated at sites of inflammation, its exact roles in this context remain uncharacterized. To address ...
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Keywords {🔍}
doi, fig, sirna, cyd, itsnps, expression, google, scholar, pubmed, cell, cells, gut, mice, delivery, vivo, colitis, sirnas, cydknockdown, silencing, mrna, pmc, leukocytes, target, cytokine, delivered, splenocytes, hours, cytokines, nlm, itsnp, cydsirna, inflammation, selectively, nanoparticles, integrin, mononuclear, entrapped, cycle, cysirna, iggsnps, mgkg, data, effects, ncbi, search, article, proliferation, antibody, expressed, presence,
Topics {✒️}
org/cgi/content/full/319/5863/627/dc1 materials β7 i-tsnps-entrapped cyd1-sirna β7 i-tsnp-induced silencing igg-snp-formulated ku70-sirna β7 i-tsnps showed β7 i-tsnps spread pro-inflammatory th1 cytokines supplementary material nihms56966-supplement pma/ionomycin-stimulated tk-1 cells supplementary materials nihms56966-supplement β7 i-tsnp β7 integrin-expressing cells cyd1-small interfering rna integrin-targeted sirna delivery i-tsnp approach tumor necrosis factor-α generating i-tsnp th2-dominant phenotype appears pmc beta search resulting stabilized nano-particles potential anti-inflammatory target cell-surface adhesion molecules leukocyte β7 integrin cell cycle independently β7 i-tsnps β7 integrin-targeted alter cytokine expression selectively silencing cyd1 pma/ionomycin-activated cells aphidicolin-treated tk-1 cells ku70 protein expression cell cycle-independent suppression mock-treated samples [ selectively suppressed generating i-tsnps β7-specific manner mrna expression supplementary materials included β7 integrin knockout systemic sirna delivery studied cyd1-knockdown tested ku70 expression anti-inflammatory therapeutics suppressing gene expression cyd1 mrna rehydrating lyophilized particles nih grants hl048675 cytokine expression targeting antibody molecule study reveals cyd1
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