
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Scratching the surface of skin development - PMC
Description:
The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and ...
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Keywords {🔍}
doi, cells, hair, pubmed, google, scholar, follicle, stem, cell, skin, epidermis, epidermal, signalling, differentiation, pmc, development, dev, article, free, nature, wnt, bulge, follicles, bmp, mice, genes, growth, sebaceous, gland, dermal, βcatenin, basal, fuchs, epithelial, proteins, placode, expression, lineage, embryonic, activation, transcriptional, proliferation, formation, role, layer, papilla, morphogenesis, factor, matrix, junctions,
Topics {✒️}
β-catenin/lef/tcf-regulated genes β-catenin/tcf/lef signalling determine edar/eda/nuclear factor-κb β-galactose-positive cells expand γ-secretase-deficient follicles fail β-galactosidase-expressing virus73 fgf10/fgf7 receptor fgfriiib negatively regulating c-myc triggers chemokine/cytokine expression86 nf-κb-independent manner97 pmc beta search presenilin-1-dependent γ-secretase β-catenin/tcf transactivation elaborate actin–myosin network ppar-γ-null mice drives β-galactosidase expression melano-blast stem cells positive-acting signalling pathways balancing c-myc expression irs include c-myc cell–cell borders increases mesenchymal–epithelial tissue recombination ccaat/enhancer binding protein bind vasodilator-stimulated phosphoprotein follicle stem-cell maintenance wnt-promoting signals converge receptor-α transcription factor wnt/β-catenin signalling13 bulge-stem-cell compartment β-catenin/lef1/tcf nf-κb kinase-α tnfr1-dependent hypoproliferative influence early epidermal–dermal discourse shh-regulatory circuit involving robust cell–cell junctions cell–cell junctions generates cell-junction adhesion complexes distinct differentiation-specific cues follicle stem-cell niche constitutively active β-catenin resident progenitor-cell population show nuclear localization control ras–mapk activity β-catenin/lef1-responsive follicle stem-cell activation e-cadherin loss promotes lysine histone demethylase label-retaining cells reside lef-1-deficient mice wild-type counterparts27
Questions {❓}
- A role for Kaiso-p120ctn complexes in cancer?
- How does the epidermis achieve all this?
- These special features seem to be lost in most cells as development proceeds, but do multipotent stem cells of the skin retain this potential?
- Where do these adult stem cells come from and when during embryonic development are they determined?
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- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Int.%20Rev.%20Cytol&title=Cell%20replacement%20in%20epidermis%20(keratopoiesis)%20via%20discrete%20units%20of%20proliferation&author=CS%20Potten&volume=69&publication_year=1981&pages=271-318&pmid=6163744&doi=10.1016/s0074-7696(08)62326-8&?
- Earnings of https://doi.org/10.1111/j.1365-2133.1970.tb12437.x
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Br.%20J.%20Dermatol&title=Variation%20in%20the%20plane%20of%20cell%20cleavage%20during%20the%20process%20of%20stratification%20in%20the%20mouse%20epidermis&author=IH%20Smart&volume=82&publication_year=1970&pages=276-282&pmid=5441760&doi=10.1111/j.1365-2133.1970.tb12437.x&
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- What's https://scholar.google.com/scholar_lookup?journal=Nature&title=p63%20is%20a%20p53%20homologue%20required%20for%20limb%20and%20epidermal%20morphogenesis&author=AA%20Mills&volume=398&publication_year=1999&pages=708-713&pmid=10227293&doi=10.1038/19531&'s gross income?
- Earnings of https://doi.org/10.1038/19539
- Find out how much https://scholar.google.com/scholar_lookup?journal=Nature&title=p63%20is%20essential%20for%20regenerative%20proliferation%20in%20limb,%20craniofacial%20and%20epithelial%20development&author=A%20Yang&volume=398&publication_year=1999&pages=714-718&pmid=10227294&doi=10.1038/19539& earns monthly
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- How much does https://doi.org/10.1038/scientificamerican1191-96 make?
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Sci.%20Am&title=Cultured%20cells%20for%20the%20treatment%20of%20disease&author=H%20Green&volume=265&publication_year=1991&pages=96-102&pmid=1785043&doi=10.1038/scientificamerican1191-96&?
- How much profit does https://doi.org/10.1073/pnas.0611358104 generate?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=Mice%20cloned%20from%20adult%20skin%20cells&author=J%20Li&author=V%20Greco&author=G%20Guasch&author=E%20Fuchs&author=P%20Mombaerts&pmid=17299040&doi=10.1073/pnas.0611358104& generate?
- Find out how much https://doi.org/10.1056/NEJM199908123410706 earns monthly
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- How much does https://www.usa.gov/ make?
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