
NCBI . NLM . NIH . GOV {
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Title[redir]:
Determinants of protein function revealed by combinatorial entropy optimization - PMC
Description:
A new algorithm is presented allows protein specificity residues to be assigned from multiple sequence alignments alone. This information can be used, amongst other things, to infer protein functions.
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Keywords {🔍}
residues, specificity, protein, doi, entropy, functional, subfamilies, sequences, number, google, scholar, conserved, sequence, pubmed, function, alignment, subfamily, binding, analysis, data, combinatorial, proteins, family, residue, superfamily, human, method, interactions, families, figure, information, alignments, sites, results, clustering, file, multiple, additional, columns, clusters, algorithm, predicted, values, prediction, site, molecular, column, gtpases, interface, biol,
Topics {✒️}
additional data files large-scale genotyping datasets pmc beta search conserved physico-chemical characteristics eukaryotic type kh-domain cyclin-dependent kinase [cdk6] supplementary materials included cdk-activating enzymatic complex predicting specificity-determining residues homology-derived secondary structure putative dna-binding domain cell cycle inhibitors residue-specific functional constraints specific protein-partner interactions references hussain sp specificity-switch experiments reveal transcription factor e2f1 discussion algorithmic innovation 𝛥 𝑆 𝑘 evolution-entropy hybrid methods cyclin-dependent kinase 17976239 short abstract column-specific difference entropies protein-protein/peptide complexes abbreviations cdk subfamily-specific conservation patterns protein structure-sequence alignments sufficiently diverse family reading evolutionary signals similar functional names planning mutation experiments data availability statements protein data bank acknowledgments acknowledgements protein kinase resource top-ranked specificity residues highly specific information current sequence collections planning mutational experiments informative evolutionary trees protein polymers encode large evolutionary intervals functionally constrained residues 𝛥 𝑄 𝑘 amino acid type combinatiorial entropy difference pmc disclaimer infer protein functions strong selective constraints yield identical lists
Questions {❓}
- If the specificity residues are randomly distributed, then what is the probability of observing A or more of the S specificity residues in the interface?
- So what fraction of specificity residues are in protein interfaces?
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