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Title[redir]:
High resolution structure of the HDGF PWWP domain: A potential DNA binding domain - PMC
Description:
Hepatoma Derived Growth Factor (HDGF) is an endogenous nuclear-targeted mitogen that is linked with human disease. HDGF is a member of the weakly conserved PWWP domain family. This 70–amino acid motif, originally identified from the WHSC1 gene, has ...
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Keywords {🔍}
domain, pwwp, hdgf, dna, structure, google, scholar, pubmed, doi, protein, residues, nmr, growth, binding, factor, proteins, pmc, cell, article, dnmtb, sequence, couplings, fig, free, site, rdcs, library, domains, structures, dnabinding, based, biol, region, interaction, noesy, hydrogen, rms, backbone, cterminal, cells, set, spectra, chemicalshift, factors, obtained, restraints, regions, observed, conserved, dipolar,
Topics {✒️}
3d water-flip-back methods cys-rich zn-binding domains 13c-edited noesy-hsqc spectra single-stranded poly-gc oligonucleotide double-stranded b-dna matching c-terminal α-helical domain hepatoma-derived growth factor platelet-derived growth factor platelet-derived growth factor 3d 15n-edited noesy maldi-tof mass spectrometry p26-f27-w28-p29 pmc beta search endogenous nuclear-targeted mitogen /t-rich dna elements 15n-1h hsqc spectra 1h-15n hsqc spectra regulating nerve-specific transcription n-terminal pwwp domain utilized talos-derived φ excess single-stranded oligomers small-cell lung cancer 3d hnco-based experiments heparin-binding growth factor calcium-free calmodulin dna-binding site elucidated potential dna-binding site [google scholar] zhou strongest chemical-shift perturbations specific dna-binding site [google scholar] cornilescu [google scholar] schlessinger candid/cyanaa 13c noesy monitor protein chemical-shift zinc finger domains protein–nucleic acid interactions analyze protein–dna interactions 13c/15n-labeled hdgf0–110 receptor tyrosine kinases side-chain chemical shifts similar chemical-shift perturbations org/cgi/doi/10 observed chemical-shift change thrombin stimulates proliferation regular β-strands based muscle-specific genes nonspecific dna-binding domain nerve growth factor 15n-1h hsqc high-resolution solution structure
Questions {❓}
- The PWWP domain: A potential protein-protein interaction domain in nuclear proteins influencing differentiation?
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