
NCBI . NLM . NIH . GOV {
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Title[redir]:
Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells - PMC
Description:
Human CD8+ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be found within the circulating human CD8+ T cell subset. First, CD45RA−CD45R0+ cells are ...
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Keywords {🔍}
cells, cdracd, cell, doi, pubmed, google, scholar, subsets, cdra, expression, population, human, immunol, memory, activity, subset, ifnγ, van, mabs, cytokine, lymphocytes, effector, data, production, perforin, found, cytolytic, cdcdracd, pmc, naive, analysis, blood, mab, tnfα, sorted, cdd, cytotoxic, cytokines, staining, fig, fas, cdb, proliferation, granzyme, table, article, primed, activation, free, open,
Topics {✒️}
goat anti–mouse conjugate 51cr-labeled autologous b-lcl full-length expressible cdna hiv-1 rt-derived peptide hiv-1lai rt gene flat-bottomed microtiter plates cd8+cd45ra+cd27− population allowed fitc-labeled cd45ro mab hla-b57 restricted epitope cd3 receptor-mediated activation fitc-conjugated antiperforin mabs pmc copyright notice van der pouw-kraan protein-secretion inhibitor monensin ficoll-paque density centrifugation cd8+t-cell subsets defined autologous b-lcl infected pmc beta search autologous b-lcl pulsed fitc-labeled cd27 mab �single-hit poisson model” fitc-conjugated cd27 mabs t-cell growth factor forward scatter/side scatter hiv-1–infected individual contained memory-type cd8+ cd45ra−cd45r0+ fitc-conjugated cd27 cells t-cell mediated cytotoxicity cd45ra−cd27− homing receptors cytotoxic t-lymphocyte epitopes t-cell memory maintained anti–human ifn-γ subsequent cd45ra−cd45r0+ stage biotinylated anti–human il-2 peptide-specific ctlp frequencies antigen-specific precursor ctl hiv-1–specific ctl precursors pe-conjugated cd45ra mabs high effector/target ratios clb-cd3/3 clb-cd3/4 pathogen-free conditions cytolytic t-cell cytotoxicity percp-labeled cd8 mab professional antigen-presenting cells fas–fas ligand interaction distinguishing unprimed cd45ra+cd27+ license information pmcid publisher site pdf cd8+cd45rahight cell population 51cr-release assay
Questions {❓}
- Is T-cell memory maintained by crossreactive stimulation?
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