
NCBI . NLM . NIH . GOV {
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Title[redir]:
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes - PMC
Description:
The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been ...
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Keywords {๐}
genes, mice, srebp, fatty, cholesterol, scap, livers, doi, scholar, pubmed, google, acid, liver, tgsrebpa, table, synthesis, srebps, increased, tgsrebp, expression, identified, transgenic, direct, criteria, fold, involved, pmc, increase, acids, protein, target, proteins, gene, targets, metabolism, family, biol, microarray, article, srebpa, decreased, nsrebp, mouse, affymetrix, abcg, brown, goldstein, function, nuclear, stringent,
Topics {โ๏ธ}
putative enoyl-coa/acyl-coa hydratase/dehydrogenase mannโwhitney ranking feature potential srebp-binding site pmc beta search cre-lox recombination system short-chain aldehyde reductase long-chain fatty acids elicit high-level expression srebp cleavage-activating protein atp-binding cassette proteins fatty acid-related genes ๏ฟฝ๏ฟฝ590-aa cooh-terminal domain supplementary materials included low-density lipoprotein receptor cholesterol-related genes tended glutathione s-transferase family membrane-bound srebp binds triglyceride-enriched fatty liver marked fold-increase values membrane-bound transcription factors nuclear receptors lxr-ฮฑ statistically significant manner acyl-coa synthetase-4 low carbohydrate diet phospholipid transfer protein dna binding assays short โ30-aa segment atp-binding cassette pnas web site membrane-bound protein low-density lipoprotein glutathione s-transferase transgenic srebp-1a mice tgsrebp-1a mouse livers 17-ฮฒ-hydroxysteroid dehydrogenase-7 oligonucleotide arrays hybridized produces glyceraldehyde-3-phosphate documented association exists unsaturated fatty acids fatty acid desaturation fatty acid synthase 17ฮฒ-hydroxysteroid dehydrogenase-7 cooh-terminal domain glutathione s-transferases nh2-terminal โ500 aa polyinosinic-polycytidylic acid shorter transactivation domain srebp binding sites srebp-binding sites wild-type mice
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