
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Redox regulation of PI 3-kinase signalling via inactivation of PTEN - PMC
Description:
The tumour suppressor PTEN is a PtdIns(3,4,5)P3 phosphatase that regulates many cellular processes through direct antagonism of PI 3-kinase signalling. Here we show that oxidative stress activates PI 3-kinase-dependent signalling via the ...
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Keywords {๐}
pten, cells, cellular, pubmed, google, scholar, doi, oxidative, activity, ptdinsp, kinase, activation, signalling, cell, pkb, data, macrophages, stress, inactivation, raw, protein, oxidation, levels, production, experiments, buffer, min, lps, pmc, suppressor, downstream, figure, phosphatase, stimulated, reducing, pathway, pma, regulation, biol, alkylation, free, article, conditions, shown, stimulation, lysis, tumour, oxidants, mechanism, growth,
Topics {โ๏ธ}
modified krebsโhenseleit buffer wild-type gfpโpten redox-dependent signal transduction phosphatase-dead pten c124s inositol-free culture medium polyscreen nen/perkin elmer pmc beta search platelet-derived growth factor monocyte-macrophage cell line p3-regulated kinase pkb/akt pkb/akt-dependent cell survival 3-phosphoinositide-dependent protein kinase-1 human monocyte-differentiated macrophages p66shc-dependent signaling pathway 1093/emboj/cdg513 redox regulation protein-tyrosine phosphatase 1b free cysteine residues nitric oxide-mediated apoptosis ref1-dependent redox mechanism pten-null u87mg cells cytokine-activated murine macrophages concomitant oxidant-dependant activation van der kaay c124s-infected cells corresponds pi 3-kinase/pkb pathway wild-type pten mmac/pten inhibits proliferation oxidative stress-induced apoptosis anti-inflammatory actions tumor suppressor pten/mmac initial cysteine-directed alkylation license information pmcid phosphoinositide 3-kinase pathway oxidative stress-induced inactivation swiss 3t3 fibroblasts activates downstream signalling cellular pten status active site cysteine pi 3-kinase pathway cold degassed buffer ice cold buffer human tumour types sulfenic acid intermediate publisher site pdf pi 3-kinase signalling fetal bovine serum cultured u87mg cells lipopolysaccharide activates akt epidermal growth factor tissue culture media
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