
NCBI . NLM . NIH . GOV {
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Title[redir]:
CD4+CD25āFoxp3ā Th1 cells are the source of IL-10āmediated immune suppression in chronic cutaneous leishmaniasis - PMC
Description:
Nonhealing forms of leishmaniasis in humans are commonly associated with elevated levels of the deactivating cytokine IL-10, and in the mouse, normally chronic infections can be cleared in the absence of IL-10. Using a Leishmania major strain that ...
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Keywords {š}
cells, mice, infection, pubmed, google, scholar, doi, major, cell, reg, production, chronic, rag, natural, ear, ifnγ, immunol, pmc, foxp, lesions, naive, parasite, article, leishmania, response, fig, regulatory, lesion, cdcd, data, free, suppression, immunity, expression, nonhealing, produced, ilproducing, source, interleukin, cdcdfoxp, leishmaniasis, responses, role, nihsd, site, immune, analysis, experiments, lymph, relative,
Topics {āļø}
c57bl/10sgsnai-[ko]il10-[ko]rag2n12 ifn-γ+t-bet+foxp3ā cells recovered org/cgi/content/full/jem post-kala-azar dermal leishmaniasis pe-cy5 antiāmouse cd4 ifn-γ/il-10 double producers fitc antiāmouse ifn-γ facs-purified naive cd4+cd25ā specific pathogen-free conditions naturally occurring cd4+cd25+foxp3+ antigen-specific cd4+cd25āfoxp3ā major nih/sdāinfected mice lesional ifn-γāproducing cd4+ c57bl/10sgsnai-[ko]il10n10 c57bl/10sgsnai-[ko]rag2 antigen-induced cd4+cd25āfoxp3ā antiāil-10 receptor antibody il-10āproducing cd4+cd25āfoxp3ā fitc antiāmouse cd103 apc antiāmouse cd25 ifn-γ+il-10+ foxp3ācd4+ direct-reading vernier caliper pmc copyright notice cd4+cd25āfoxp3ā cells provide major strain nih/sd major nih/sd strain pmc beta search cell contactādependent mechanisms infective-stage metacyclic promastigotes increase antigen-specific proliferative flat-bottom microtiter plates th2 cellāpolarizing conditions t-cell phenotypes cellāderived il-10 exerted bone marrowāderived dc pe antiāmouse il-10 antigen-specific cytokine secretion th1 cellāpolarized setting major nih/sd infection online supplemental material simultaneously produce ifn-γ il-10āmediated suppressive pathways parasite-driven th1 responses naive foxp3-gfp knock il-12-induced immune responses ifn-γāproducing cd4+ antigen-specific il-10 production il-4rαādeficient mice cd25+cd4+ tr cells cd4+cd25+cd103+foxp3+
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