
NCBI . NLM . NIH . GOV {
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Title[redir]:
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells - PMC
Description:
Oral tolerance induction is a key feature of intestinal immunity, generating systemic nonresponsiveness to ingested antigens. In this study, we report that orally applied soluble antigens are exclusively recognized in the intestinal immune system, ...
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Keywords {🔍}
antigen, cells, mln, tolerance, oral, induction, mice, intestinal, cell, pubmed, google, scholar, doi, immune, lymphoid, proliferation, dcs, fty, fig, system, mesenteric, antigens, feeding, wildtype, peripheral, ccrdeficient, intestine, pbs, administration, organs, ovalbumin, pln, immunol, antigenspecific, treatment, spleen, ccr, pmc, lymph, data, dendritic, recognition, observed, lymphocytes, depicted, lymphocyte, systemic, lymphadenectomy, adoptively, transferred,
Topics {✒️}
agonistic anti-lymphotoxin–β-receptor antibody tailed nonparametric mann-whitney-test org/cgi/content/full/jem bone marrow-derived apc αe-integrin chain cd103 specific pathogen-free conditions lymphotoxin-α–deficient mice pmc beta search pmc copyright notice anti-cd8α–allophycocyanin–cy7 t-cell response elicited high-dose feeding regimen sphingosine-1–phosphate receptor signaling vα2/vβ5-positive lymphocytes high-dose oral tolerance ccr7-mediated cell migration meet ln-resident dcs wild-type “reporter” mice syngenic wild-type recipients fluorescent dye–coupled antibodies unmanipulated wild-type controls online supplemental material anti-cd11b–pe-cy7 ovalbumin-specific ear swelling ccr7-deficient lymphoid organs 1 μg/ml dapi/tbst adoptively transferred antigen-specific unmanipulated wild-type mice primary immune response orally administered antigen ccr7-dependent cell migration ccr7-deficient mice compared monitor fty720-induced lymphopenia license information pmcid tolerized wild-type mice ovalbumin-specific tcr-transgenic analyzing ccr7-deficient mice free antigen entering left ear pinna orally applied antigens sphingosine 1-phosphate receptor-1 publisher site pdf site-specific expression receive afferent lymph 5 mg/ml collagenase mesenteric lymph nodes delayed type hypersensitivity commensal bacteria constitute remain immunologically inconspicuous antigen-challenged intestine react
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