
NCBI . NLM . NIH . GOV {
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Title[redir]:
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase - PMC
Description:
The treatment of ischemic strokes is limited to prophylactic agents that block the coagulation cascade. Here, we show that cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, protect against cerebral injury by a ...
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Keywords {🔍}
doi, sim, mice, enos, google, scholar, pubmed, cerebral, treatment, hmgcoa, reductase, inhibitors, blood, cbf, mca, cholesterol, levels, occlusion, mgkg, infarct, effects, serum, days, ischemic, expression, activity, stroke, nos, size, compared, enosdeficient, ischemia, huang, flow, deficits, endothelial, moskowitz, agents, group, control, neurological, pmc, strokes, lov, animals, determined, absolute, table, baseline, statins,
Topics {✒️}
n-isopropyl-p-iodo[methyl-1 ca2+-dependent [14c]citrulline assay hmg-coa reductase inhibitors hmg-coa reductase inhibitor semiquantitative reverse transcription–pcr hepatic hmg-coa reductase mann–whitney rank sum hmg-coa reductase compared ttc-stained brain sections pmc beta search neurological sensory-motor deficits coa reductase inhibitors 129/sv wild-type mice c57bl/6 wild-type mice vehicle-injected enos-deficient mice blood gas/ph analyzer publisher site pdf augmented blood flow enos-deficient mice treated [14c]citrulline conversion assay enos-deficient mice indicating semiquantitative competitive pcr donor augments cbf cerebral blood flow large clinical trials vehicle-injected 129/sv mice nos catalytic activity license information pmcid middle cerebral artery cerebral infarct size chronic statin administration wild-type mice wild type mice nos activity assay pheochromocytoma cell lines pcr cycle consisted concentration-dependent manner cerebral infarct sizes decreases cerebral ischemia increasing blood flow resting blood flow previous clinical studies cerebral infarct volume time-dependent effects arterial blood samples central nervous system taking statin therapy concentration-dependent effects statin-treated mice cerebral infarct volumes
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