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Keywords {🔍}

eife, mnk, doi, cells, translation, mcl, phosphorylation, lowe, pubmed, google, scholar, fig, cell, tumor, cordoncardo, sonenberg, mutant, tumors, apoptosis, pandolfi, pelletier, phosphorylated, expressing, activated, wendel, protein, pmc, tumorigenesis, lymphoma, signaling, gfp, mefs, cancer, initiation, vivo, cooper, article, mice, lymphomas, transduced, factor, kinase, target, hscs, vector, penn, kogan, genes, human, expression,

Topics {✒️}

mnk-expressing mscv-ires-gfp-based vector eμ-myc/eif4e tumor-bearing mouse quantitative real-time rt–pcr oppose c-myc-induced apoptosis c-myc-expressing wild-type eμ-myc/tsc2−/− tumor cells eμ-myc/p53+/− hscs transduced pmc beta search short-term lymphoma cultures eμ-myc hscs expressing eμ-myc/p53+/− hscs mitogen-activated protein kinase initial stem/progenitor cells wild-type p53 allele rapamycin-chemotherapy drug combinations eμ-myc/tsc2−/− lymphomas eμ-myc hscs transduced facs-purified tumor cells potential anti-apoptotic target prevent mnk-induced phosphorylation anti-apoptotic protein mcl-1 tsc2-null lymphomas activate selective anti-tumor activity c-myc protein serine/threonine kinases mnk1 gfp-expressing retroviral vectors kaplan-meier analysis general translation factor substantially accelerated lymphomagenesis rapamycin-mediated mammalian target wild-type p53 mscv-ires-gfp eμ-myc system translation initiation apparatus t2a2-expressing lymphoma cells myc-induced lymphomagenesis eμ-myc/arf−/− eif4e-binding proteins adoptive transfer methods publisher site pdf eμ-myc model wild-type cells cap-dependent translation wild-type eif4e semiquantitative rt–pcr rt–pcr primers conserved phosphorylation site license information pmcid ribosome translate cancer protein kinase mnk1

Questions {❓}

• Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?
• Does the ribosome translate cancer?

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