
NCBI . NLM . NIH . GOV {
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Title[redir]:
Ageing, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity โ catalysts of autoimmunity and chronic inflammation - PMC
Description:
Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults, with the highest incidence rates reported in the elderly. The immune system undergoes profound changes with advancing age that are beginning to be understood ...
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Keywords {๐}
cells, doi, pubmed, google, scholar, tcell, arthritis, naive, patients, diversity, rheumatoid, tcr, goronzy, weyand, cell, memory, immunol, repertoire, clonal, pmc, disease, proliferation, senescent, expression, article, coronary, free, senescence, immune, homeostasis, increased, loss, contraction, homeostatic, cdcdnull, regulatory, functional, compartment, replicative, system, age, thymic, control, frequency, tissue, autoimmune, studies, receptor, populations, receptors,
Topics {โ๏ธ}
t-cell-deficient host induces classic cd28-cd80/cd86 pathway pmc beta search t-cell populations play t-cell-mediated lysis oligoclonal t-cell populations competing interests c-type lectin family altered t-cell homeostasis clonal t-cell populations resemble t-cell oligoclonality references davis mm expanded t-cell clones autoreactive t-cell responses autoreactive t-cell response monoclonal t-cell proliferation tcrโpeptideโmhc complex aging t-cell compartment t-cell effector functions ifn-ฮณ-inducible genes ifn-ฮณ receptor triggering antigen-driven activation event organ-specific autoimmunity induced c-reactive protein [83] c-reactive protein memory t-cell compartment cellular t-cell senescence responding t-cell population naive t-cell compartment professional antigen-presenting cells diverse t-cell repertoire ifn-ฮณ-mediated activation cd28-specific initiator complex cd8+ t-cell population naive t-cell response publisher site pdf human nk-cell receptors increased ifn-ฮณ activity cd4+ t-cell diversity tcr ฮฒ-chain coronary artery disease functional t-cell repertoire extra-articular rheumatoid arthritis coronary artery lesion clonally expanded cd28-cd8+ age-matched healthy controls cd11b+cd28-cd4+ human clonally expanded cd4+cd28 douek dc t-cell populations
Questions {โ}
- Replicative senescence: an old lives' tale?
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- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=Directly%20measured%20kinetics%20of%20circulating%20T%20lymphocytes%20in%20normal%20and%20HIV-1-infected%20humans&author=M%20Hellerstein&author=MB%20Hanley&author=D%20Cesar&author=S%20Siler&author=C%20Papageorgopoulos&volume=5&publication_year=1999&pages=83-89&pmid=9883844&doi=10.1038/4772&
- See how much https://github.com/ncbi makes per month
- What's the total monthly financial gain of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
- https://www.nlm.nih.gov/web_policies.html's total income per month
- How much does https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office generate monthly?
- How much does https://www.hhs.gov/vulnerability-disclosure-policy/index.html gross monthly?
- https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal's financial summary
- How much does https://www.nlm.nih.gov/accessibility.html make?
- How much profit is https://www.nlm.nih.gov/careers/careers.html making per month?
- Earnings of https://www.nlm.nih.gov/
- How much does https://www.nih.gov/ net monthly?
- How much does https://www.hhs.gov/ make?
- How much does https://www.usa.gov/ make?
Analytics and Tracking {๐}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {๐}
- Foundation
- jQuery
- jQuery module (jquery-3.6.0)
Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {๐ฆ}
- Ncbi