
NCBI . NLM . NIH . GOV {
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Title[redir]:
Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants - PMC
Description:
The success of targeting kinases in cancer with small molecule inhibitors has been tempered by the emergence of drug-resistant kinase domain mutations. In patients with chronic myeloid leukemia treated with ABL inhibitors, BCR-ABL kinase domain ...
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Keywords {π}
doi, kinase, bcrabl, tyr, phosphorylation, pubmed, google, scholar, mutants, activity, fig, ploop, cells, oncogenicity, mutations, mutant, transformation, mutation, drugresistant, pmc, cancer, wildtype, drug, relative, resistance, potency, article, fitness, oncogenic, assay, abl, analysis, inhibitor, cell, data, patients, detected, dasatinib, cml, resistant, mass, bone, marrow, phosphorylated, science, context, residue, substrates, substrate, expressing,
Topics {βοΈ}
il-3-dependent ba/f3 cells org/cgi/content/full/0609239103/dc1 drug-resistant bcr-abl mutants drug-resistant bcr-abl mutations bcr-abl p-loop phosphorylation control ba/f3 cells wild-type p210 bcr-abl primary p-loop determinant kinase inhibitor-resistant mutants drug-resistant mutants isolated phosphorylated/unphosphorylated p-loop tyrosines drug-resistant hiv strains bcr-abl p-loop total bcr-abl cdna entire bcr-abl pool bcr-abl kinase domain drug-resistant kinase oncogenes bcr-abl mutations capable wild-type bcr-abl imatinib-related compound nilotinib mutation-specific pharmacodynamic monitoring p-loop tyrosines directs abl p-loop peptide regulating bcr-abl oncogenicity altered p-loop phosphorylation bcr-abl mutant transformation bcr-abl kinetics studies classical bcr-abl substrates mutation-specific phosphotyrosine signatures drug-resistant allele functions p-loop phosphorylation pattern mutation-specific quantitative pcr t315i-expressing cells differed dasatinib-resistant cml patient p-loop peptide phosphorylation pmc beta search bcr-abl transformation potential mutation-specific phosphorylation pattern serine/threonine kinase cdk2 p-loop tyrosines plays modified whitlockβwitte pre t315i bcr-abl mutation gel-based kinase assays abl inhibitor imatinib bcr-abl mutants mass spectrometry ion compound tyr253/thr315 mutations drug resistant mutations bcr-abl single abl p-loop
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