
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707 - PMC
Description:
The regulation of telomerase reverse transcriptase (TERT) plays an important role in the proliferative capacity and survival of cells. Here, we report that exogenously as well as endogenously induced oxidative stress leads to translocation of ...
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Keywords {🔍}
nuclear, htert, cells, doi, pubmed, google, scholar, telomerase, antibody, cell, export, tert, shown, ran, fig, activity, phosphorylation, tyrosine, oxidative, incubated, kinase, nucleus, stress, panels, enzyme, fractions, pmc, biol, staining, apoptosis, cytosolic, panel, free, localization, telomere, htertwt, overexpressing, src, ros, article, analysis, min, endogenous, myctagged, translocation, protein, htertyf, lower, upper, data,
Topics {✒️}
nac inhibited tnf-α/chx-induced dominant-negative gtpase-deficient mutant amyloid beta-peptide-induced apoptosis keratinocyte-targeted telomerase-transgenic mice 6-bp telomerase-specific ladder src kinase-dependent phosphorylation pmc beta search prevent stress-induced senescence c-abl tyrosine kinase tyrosine kinase c-abl profound time-dependent change biotin-labeled ts primers streptavidin-coated microtiter plate telomerase-mediated dna laddering enzyme-linked immunosorbent assay extracellular signal-regulated kinase polyethylene glycol-superoxide dismutase age-dependent telomere shortening biotin-labeled secondary antibody myc-tagged ran q69l src kinase family fluorescence-activated cell sorter myc-tagged htert protein ros-induced nuclear export h2o2-induced nuclear export ran gtpase-dependent process crm1/ran-dependent manner telomerase-transgenic mice showed h2o2-stimulated nuclear export src family kinases regulated nucleo/cytoplasmic exchange oxidative stress induces mammalian thioredoxin system myc directly conjugated enhanced chemiluminescence system tnf-α/chx treatment nuclear targeting sequences regulate signaling pathways human telomerase induced reactive oxygen species normal human fibroblasts telomerase reverse transcriptase crm1-ran-dependent transport protein kinase activity ran-independent transport pathway stat1 transcription factor ros-dependent apoptosis induction smooth muscle cells rap1-dependent pathways protein kinase calpha
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- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi