
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mycobacterium leprae Is Naturally Resistant to PA-824 - PMC
Description:
Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of ...
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Keywords {🔍}
leprae, mycobacterium, tuberculosis, pubmed, google, scholar, mice, doi, activity, pmc, fig, rifampin, bacilli, article, leprosy, effect, mouse, agents, free, nude, footpads, balbc, animals, treatment, method, antimicrob, chemother, macrophages, treated, control, models, viability, radiorespirometry, shown, nlm, months, drug, bactec, μgml, counts, growth, weeks, vitro, axenic, intracellular, measured, model, efficacy, mgkg, genes,
Topics {✒️}
f420-dependent glucose-6-phosphate dehydrogenase nitroimidazo-oxazine-specific protein involved nitroimidazopyran-based selection system 60-fold-higher inherent resistance classical nadp+-dependent genes pmc beta search nitroimidazo-oxazine-specific nitroreductase 4-nitroimidazo-oxazine compound active nu/nu mouse-derived detectable nadp-g6pd activity counting acid-fast bacteria publisher site pdf f420-dependent g6pd activity nu/nu nude mice glucose-6-phosphate dehydrogenase athymic nu/nu mice infected nu/nu mice pentose phosphate pathway f420-dependent genes bicyclic 4-nitroimidazo-oxazines conserved hypothetical protein 614 protein-encoding genes nude mouse-derived methods bacterial strains bactec pza media license information pmcid mouse foot pad nude mouse model united states government important lead compound fetal calf serum 10% hydroxypropyl-β-cyclodextrin bar graphs show electron redox reactions transposon tn5367 mutagenesis massive gene decay high-throughput screening antituberculous candidate opc-67683 7h11 agar medium mouse footpad model direct microscopic count annotated g6pd genes closely related actinomycetes multiple drug therapy acid-fast bacteria pmc disclaimer serial dilution plating related bicyclic nitroimidazoles tuberculosis-infected macrophages treated mouse efficacy studies
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