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Title[redir]:
Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation - PMC
Description:
We describe a double-transgenic mouse strain (opticospinal EAE [OSE] mouse) that spontaneously develops an EAE-like neurological syndrome closely resembling a human variant of multiple sclerosis, Devic disease (also called neuromyelitis optica). ...
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Keywords {🔍}
mice, cells, doi, ose, disease, figure, google, scholar, pubmed, mog, cell, transgenic, eae, tcrmog, autoimmune, ighmog, animals, lesions, spinal, singletransgenic, cns, spontaneous, doubletransgenic, rmog, pmc, mouse, antibodies, supplemental, splenocytes, article, devic, optic, cord, myelin, clinical, free, multiple, lymphocytes, healthy, sick, sclerosis, demyelinating, peptide, cbl, data, analysis, immunol, encephalomyelitis, human, antimog,
Topics {✒️}
triple-transgenic tcrmog×ighmog×mog–/– animals age-matched single-transgenic ighmog isotype-specific anti-mouse ig gated cd4+cd3+ double-positive tcrova×ighmog double-transgenic mice double-transgenic tcrova×ighmog mice tcrmog×ighmog double-transgenic animals fam/tamra taqman probes quantitative real-time pcr 3-ethyl-benzthiazoline-6-sulphonic acid fluorescence-activated cell sorting double-transgenic mice expressing intact b-cell activity myelin basic protein-specific ighmog single-transgenic littermates develop optic neuritis double-transgenic mouse model double-transgenic mouse strain receptor-mediated antigen uptake tcrmog ×ighmog double-transgenic myelin/oligodendrocyte glycoprotein–deficient pmc beta search cd11b+ macrophage/monocyte component healthy single-transgenic tcrmog pmc copyright notice ighmog single-transgenic animals anti-mog igs underwent ighmog single-transgenic mice myelin oligodendrocyte glycoprotein–specific myelin oligodendrocyte glycoprotein-specific tcrmog single-transgenic mice single-transgenic tcrmog mice double-transgenic mice housed double-transgenic spleen cultures live-gated cd4+cd3+ single-transgenic ighmog splenocytes showed activated antigen-specific ose double-transgenic mice single-transgenic parental mice demyelinating mog-specific antibody similar supra-additive effect single-transgenic tcrmog spleens gene-targeted transgenic mice proteolipid protein–reactive constitutive β-cell expression specific pathogen–free bound anti-mog ig ig-producing plasma cells anti-mog igg1 antibodies publisher site pdf
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