
NCBI . NLM . NIH . GOV {
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Title[redir]:
Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti–Cytotoxic T-Lymphocyte Antigen-4 - PMC
Description:
Previously, we reported our experience treating 14 patients with metastatic melanoma using a fully human antibody to cytotoxic T-lymphocyte antigen-4 (anti–CTLA-4) in conjunction with peptide vaccination. We have now treated 56 patients to evaluate ...
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Keywords {🔍}
patients, doi, pubmed, google, scholar, response, lung, mgkg, ctla, cells, cohort, autoimmune, patient, antictla, dose, autoimmunity, peptide, toxicity, cell, grade, cancer, treatment, pmc, melanoma, liver, experienced, free, tumor, regression, article, tcell, expression, table, cdcd, antigen, weeks, clinical, disease, mediastinum, immunol, metastatic, treated, vaccination, received, doses, objective, activation, previous, colitis, previously,
Topics {✒️}
granulocyte/macrophage colony-stimulating factor enzyme-linked immuno-spot anti–ctla-4 monoclonal antibody cancer-bearing organs targeted cytotoxic t-lymphocyte antigen-4 enzyme-linked immunosorbent assays fluorescence-activated cell sorter total t-cell/apc interaction selected t-cell markers antagonizes t-cell activation unopposed t-cell activation pmc beta search grade iii/iv toxicity adoptive-cell-transfer therapy studied t-cell receptors cd8 t-cell markers humanized anti–ctla-4 antibody low-dose bolus il-2 bound anti–ctla-4 ab pmc copyright notice cd28 ligand b7/bb1 fully human antibody pg/ml ifn-γ 100 pg/ml ifn-γ remains cancer free selected animal models class ii-restricted peptides primary immune response tetramer-reactive cd8+ cells grade iii/iv received high-dose corticosteroids publisher site pdf t-cell activation enhanced ctla-4 expression antigen-presenting cell fluorochrome-labeled antibodies perivascular lymphocytic infiltrate predominantly lymphocytic infiltrate systemic lupus erythematosus develop effector mechanisms costimulation-dependent activation resected stage iii t-cell receptor showing mononuclear cells serum antithyroglobulin ab develop progressive personality ctla-4-mediated inhibition cell cycle progression cd3+cd8+ intraepithelial lymphocytes t-cell response
Questions {❓}
- CTLA-4 in autoimmune diseases: A general susceptibility gene to autoimmunity?
- In the current study, we have treated an additional 15 patients with the 3 mg/kg dose regimen of anti–CTLA-4 originally used, and have treated a second cohort of 27 patients to evaluate whether decreasing the maintenance dose from 3 to 1 mg/kg would reduce the incidence of significant autoimmune toxicity, and if so, would this dose reduction influence the regression of established tumors?
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