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Title[redir]:
Metabolomics: building on a century of biochemistry to guide human health - PMC
Description:
Medical diagnosis and treatment efficacy will improve significantly when a more personalized system for health assessment is implemented. This system will require diagnostics that provide sufficiently detailed information about the metabolic status ...
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Keywords {🔍}
doi, metabolic, health, metabolites, cholesterol, google, scholar, metabolism, data, pubmed, disease, metabolomics, assessment, individual, individuals, knowledge, quantitative, analytical, biological, pathways, mass, nmr, approach, metabolite, samples, information, technologies, research, single, human, databases, drugs, diseases, biochemistry, spectrometry, plasma, pmc, metabolomic, specific, based, strategy, high, substrate, nlm, provide, produced, including, platforms, capable, sample,
Topics {✒️}
peroxisome proliferator-activated receptor unique n-dimensional clusters phytosterol ester-enriched margarine gas chromatography-mass spectrometry anti-inflammatory compounds produced [google scholar] shoda nutrient-related metabolic fingerprints pmc beta search high-content analytical strategy lipid metabolome-wide effects nih grant es11269 publisher site pdf 1h-nmr-based metabonomics biologically relevant metabolites high resolution spectra absorb cholesterol inordinately high content assays metabolism-based diseases fail analytically expedient clusters united states government guide human health proton magnetic resonances final edited form improved food supply grand challenge establishing directly comparable datasets 7-α-hydroxy-4-cholesten-3 cucurbita maxima phloem spies-faber ej osteoarthritic guinea pigs 7alpha-hydroxy-4-cholesten-3 modern mass spectrometry human genome initiative human breast tumors license information pmcid targets intestinal absorption additional analytical data health states define quantitative internal standards semi-quantitative assays unassigned statistical variables healthy versus diseased achieve fully personalized bile acid syntheses fit metabolic models microarray analysis reveals multivariate statistical analysis lack high-content influence pathway fluxes current biomarker assays
Questions {❓}
- How can one prescribe a course of action to modulate dysregulated metabolism that has a pathological trajectory if the basis of the dysregulation in metabolism is not known?
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