
NCBI . NLM . NIH . GOV {
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Title[redir]:
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - PMC
Description:
Metastasis is the spread of cancer cells from primary tumours to distant organs and is the cause of 90% of cancer deaths globally1,2. Metastasizing cancer cells are uniquely vulnerable to immune attack, as they are initially deprived of the ...
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Keywords {🔍}
cells, data, fig, cell, mice, arhgef, txa, aspirin, extended, doi, pubmed, google, scholar, source, metastasis, lungs, expression, cancer, frequency, arhgefdeficient, wildtype, experiments, cwt, vehicle, pmc, activation, analysis, antibodies, biolegend, article, cox, injection, cko, flow, cytometry, gene, days, min, cdcre, analogue, xlsx, free, lung, inhibitor, independent, anticd, immunity, antimetastatic, tumour, supplementary,
Topics {✒️}
terminally exhausted tim3+tigit+tox+cd39+tcf1low progenitor exhausted slamf6+tim3−tigit−tcf1hi optimized retroviral mscv-sgrna-puro-thy1 poly-d-lysine-coated 10-cm plates peer review information tables author contributions online content anti-perk t202/y204-af488 anti-perk t202/y204 af488 author contributions 000 gy total-body γ-radiation org/gsea/msigdb/human/genesets anti-perk t202/y204-af647 illuminating g-protein-coupling selectivity footnotes publisher competing interests anti-cd127-pe-cy7-a7r34 arhgef1-ko mmtv-pymt mice peer review t-bet transcription factor tailed mann–whitney u-test enzyme-linked immunosorbent assay anti-cd3 antibody-coated coverslips rabbit anti-mouse pten uppermost platelet-rich plasma restore anti-tumor immunity transgenic mouse model anti-tigit-pe-dazzle platelet-derived thromboxane a2 anti-cd25-pe-cy7 license information pmcid naive facs-sorted wild-type anti-cd69-pe-dazzle soluble anti-cd3ε antibody txa2-driven suppression mediated consecutive z-slices selected anti-ps6 s235/6-pe identified ga12/13-coupled gpcrs g-protein subunits gα12 cross-volume image stack identified gα12/13-coupled gpcrs enhances anti-metastatic immunity lonza 4d-nucleofector system anti-ki67-percp-ef710 anti-st2-percp-ef710 potent tumor-specific lymphocytes tcr-driven s6 phosphorylation pmc beta search effective anti-metastatic immunotherapies gα12/13-coupled txa2 receptor
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