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Title[redir]:
Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E. coli ribosome - PMC
Description:
The kinetic mechanism of elongation factor Tu (EF-Tu)-dependent binding of Phe-tRNAPhe to the A site of poly(U)-programmed Escherichia coli ribosomes has been established by pre-steady-state kinetic experiments. Six steps were distinguished ...
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Keywords {🔍}
doi, pubmed, google, scholar, elongation, factor, pmc, biol, binding, article, nlm, ribosome, ribosomes, gtp, free, site, kinetic, coli, wintermeyer, rodnina, ncbi, search, escherichia, conformational, thompson, chem, sci, protein, embo, complex, eftu, mol, proc, natl, acad, pnas, accuracy, mechanism, aminoacyltrna, rate, conformation, references, structure, rna, biochemistry, bia, dix, mar, aug, dec,
Topics {✒️}
pre-steady-state kinetic experiments elongation factor ef-tu-gdp pmc beta search guanosine-5'-triphosphatase activity dependent aminoacyl-trna ternary complexes ternary complex ef-tu codon-dependent conformational change aminoacyl-trna-independent reactions ef-tu conformation switches full text elongation factor tu h-ras p21 subsequent codon recognition aminoacyl transfer rna polypeptide chain elongation elongation cycle determine license information pmcid local conformational change trends biochem sci codon-induced conformational united states government takes place independently peptide bond formation beta conformational switch biochim biophys acta transient conformational states synonymous codons differ high fidelity selection pmc disclaimer selected references mg2+-dependent manner internal kinetic standard gdp-bound form escherichia coli ribosomes a-site binding escherichia coli ribosome publisher site pdf paromomycin binding induces refined crystal structure genetic coding interactions subsequent chemical steps elemental rate constants ribosome binding catalyzed biochem cell biol search log complete list vivo translation rates aminoacyl-trna articles links article
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