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Title[redir]:
Characteristic roadmap of linker governs the rational design of PROTACs - PMC
Description:
Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically degrade proteins responsible for the disease. PROTAC is characterized by its ...
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Ncbi.nlm.nih.gov operates using WORDPRESS.
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Keywords {🔍}
doi, protac, linker, google, scholar, pubmed, protacs, chem, linkers, pmc, article, free, design, protein, med, degradation, complex, biodegradation, ternary, efficacy, crbn, cancer, vhl, wang, targeting, length, ligand, discovery, cell, permeability, potent, model, optimization, poi, drug, binding, brd, group, selective, zhang, site, properties, linkage, fig, receptor, biol, type, stability, liu, characteristics,
Topics {✒️}
//wwwarvinascom/wp-content/uploads/2023/05/protein-degradation-therapeutics-protac-drug-discovery solvent-exposed t-butyl ester copper-catalyzed azide‒alkyne cycloaddition bcl-xl-dt2216-vhl ternary complex ortho-f4-azobenzene fragments introduced ttr-aβ protein‒protein interaction peptide-directed ubiquitin–proteasome degradation light-controlled small-molecule tool halotag-targeted sirtuin-rearranging ligand trim37-amplified breast cancer castration-resistant prostate cancer deep encoder-decoder network drug-resistant mouse models drug-likeness rules tailored proteolysis-targeting chimera modeling photo-switchable-based linkers41 bio-orthogonal click chemistry48 proteolysis-targeting chimera technology pmc beta search octanol‒water partition coefficients protein-catalyzed capture agents proteolysis-targeting chimera molecules kras-induced cancer treatment175 hydrocarbon–water partition coefficient light-induced protein degradation keap1-dependent peptide protac homogeneous time-resolved fluorescence ge-fei hao reviewed solvent-exposed hbd count stable low-energy complex93 b-cell malignancies specifically degrade proteins responsible sos-mediated cross-activation half-maximal degradation concentration stabilized peptide-based protacs clear structure–activity relationship215 pro-inflammatory cytokines biosynthesis flow-based autoregressive model mapk-activated protein kinases n-acetyl piperidine group eml4-alk oncogenic fusions small‒molecule protac degraders treating kras-driven cancers protac-mediated ternary complexes photo-controlled protac linkers lenalidomide-based protac library decoy oligonucleotide-based protac poi-protac-e3 ternary complex ternary complex poi-protac-e3 estrogen receptor-targeting protacs
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- Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?
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- Explore the financials of https://doi.org/10.1021/acs.jmedchem.1c01576
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=J%20Med%20Chem&title=Amide-to-ester%20substitution%20as%20a%20strategy%20for%20optimizing%20PROTAC%20permeability%20and%20cellular%20activity&author=V.G.%20Klein&author=A.G.%20Bond&author=C.%20Craigon&author=R.S.%20Lokey&author=A.%20Ciulli&volume=64&publication_year=2021&pages=18082-18101&pmid=34881891&doi=10.1021/acs.jmedchem.1c01496&?
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- What's the monthly money flow for https://doi.org/10.1007/BF00232899?
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=J%20Med%20Chem&title=Nonclassical%20size%20dependence%20of%20permeation%20defines%20bounds%20for%20passive%20adsorption%20of%20large%20drug%20molecules&author=C.R.%20Pye&author=W.M.%20Hewitt&author=J.%20Schwochert&author=T.D.%20Haddad&author=C.E.%20Townsend&volume=60&publication_year=2017&pages=1665-1672&pmid=28059508&doi=10.1021/acs.jmedchem.6b01483&?
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- Get to know https://doi.org/10.1016/j.ddtec.2004.11.007's earnings
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- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=J%20Med%20Chem&title=Lipophilic%20permeability%20efficiency%20reconciles%20the%20opposing%20roles%20of%20lipophilicity%20in%20membrane%20permeability%20and%20aqueous%20solubility&author=M.R.%20Naylor&author=A.M.%20Ly&author=M.J.%20Handford&author=D.P.%20Ramos&author=C.R.%20Pye&volume=61&publication_year=2018&pages=11169-11182&pmid=30395703&doi=10.1021/acs.jmedchem.8b01259&?
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- What's the revenue for https://doi.org/10.1021/jm5011258?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=J%20Med%20Chem&title=Structure-guided%20design%20and%20optimization%20of%20small%20molecules%20targeting%20the%20protein%E2%80%92protein%20interaction%20between%20the%20von%20Hippel-Lindau%20(VHL)%20E3%20ubiquitin%20ligase%20and%20the%20hypoxia%20inducible%20factor%20(HIF)%20alpha%20subunit%20with%20in%C2%A0vitro%20nanomolar%20affinities&author=C.%20Galdeano&author=M.S.%20Gadd&author=P.%20Soares&author=S.%20Scaffidi&author=I.%20Van%20Molle&volume=57&publication_year=2014&pages=8657-8663&pmid=25166285&doi=10.1021/jm5011258&?
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- Financial intake of https://scholar.google.com/scholar_lookup?journal=Bioorg%20Med%20Chem%20Lett&title=Proteolysis%20targeting%20chimeras%20(PROTACs)%20in%20%E2%80%98beyond%20rule-of-five%E2%80%99%20chemical%20space:%20recent%20progress%20and%20future%20challenges&author=S.D.%20Edmondson&author=B.%20Yang&author=C.%20Fallan&volume=29&publication_year=2019&pages=1555-1564&pmid=31047748&doi=10.1016/j.bmcl.2019.04.030&
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- Income figures for https://doi.org/10.3390/cancers13215417
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=Cancers&title=Androgen%20receptor%20signaling%C2%A0in%20prostate%20cancer%20and%20therapeutic%20strategies&author=A.%20Jacob&author=R.%20Raj&author=D.B.%20Allison&author=Z.W.%20Myint&volume=28&publication_year=2021&pages=5417&pmid=34771580&doi=10.3390/cancers13215417& is on a monthly basis
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- Financial intake of https://doi.org/10.1016/j.jsb.2014.10.010
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