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Title:
Reparative inflammation takes charge of tissue regeneration | Nature
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Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.
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pubmed, google, scholar, cas, central, cell, nature, regeneration, intestinal, liver, cells, ads, stem, signaling, cancer, inflammation, immunol, epithelial, rev, article, immunity, drosophila, activation, karin, access, role, sci, usa, receptor, research, control, growth, factor, proc, natl, acad, biol, med, mice, tissue, repair, tumor, nfκb, function, content, clevers, adult, dev, pathway, interleukin,
Topics {✒️}
iκb-kinaseβ-dependent nf-κb activation privacy policy nature portfolio c-jun/ap-1-dependent expression author information authors wnt/β-catenin signaling contributes tnf-induced intestinal nf-κb p38 mapk activity advertising tnf-α-induced liver injury permissions reprints european research council social media wnt/c-myc signaling wnt/β-catenin signaling tnfα-induced cell death ovarian research epithelial stem-cell compartments cytokine-driven compensatory proliferation inducing c-flipl turnover double-blind pilot study alpe d'huzes/kwf intestinal label-retaining cells gp130-mediated stat3 activation promotes chemical hepatocarcinogenesis lupus research cell-mediated murine hepatitis epithelial gp130/stat3 functions tumor necrosis factor hippo-independent yap signalling nature cell biol β-catenin signaling personal data crucial tumour-promoting function focal adhesion kinase lgr5 stem cells yap-dependent induction intestinal epithelial cells adult human liver springerlink instant access intestinal stem cells data protection immature progenitor cells interleukin-17 family members permissions information stem cells reside initiates tissue repair sustained jnk activation stem cell homeostasis nf-κb inhibition
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- Liver stem cells, where art thou?
- The inflammation-fibrosis link?
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headline:Reparative inflammation takes charge of tissue regeneration
description:Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.
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description:Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.
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