We are analyzing https://link.springer.com/article/10.1007/s00439-020-02227-2.

Title:
Towards systematic nomenclature for cell-free DNA | Human Genetics
Description:
Cell-free DNA (cfDNA) has become widely recognized as a promising candidate biomarker for minimally invasive characterization of various genomic disorders and other clinical scenarios. However, among the obstacles that currently challenge the general progression of the research field, there remains an unmet need for unambiguous universal cfDNA nomenclature. To address this shortcoming, we classify in this report the different types of cfDNA molecules that occur in the human body based on its origin, genetic traits, and locality. We proceed by assigning existing terms to each of these cfDNA subtypes, while proposing new terms and abbreviations where clarity is lacking and more precise stratification would be beneficial. We then suggest the proper usage of these terms within different contexts and scenarios, focusing mainly on the nomenclature as it relates to the domains of oncology, prenatal testing, and post-transplant surgery surveillance. We hope that these recommendations will serve as useful considerations towards the establishment of universal cfDNA nomenclature in the future. In addition, it is conceivable that many of these recommendations can be transposed to cell-free RNA nomenclature by simply exchanging “DNA” with “RNA” in each acronym/abbreviation. Similarly, when describing DNA and RNA collectively, the suffix can be replaced with “NAs” to indicate nucleic acids.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

WebPage:
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         headline:Towards systematic nomenclature for cell-free DNA
         description:Cell-free DNA (cfDNA) has become widely recognized as a promising candidate biomarker for minimally invasive characterization of various genomic disorders and other clinical scenarios. However, among the obstacles that currently challenge the general progression of the research field, there remains an unmet need for unambiguous universal cfDNA nomenclature. To address this shortcoming, we classify in this report the different types of cfDNA molecules that occur in the human body based on its origin, genetic traits, and locality. We proceed by assigning existing terms to each of these cfDNA subtypes, while proposing new terms and abbreviations where clarity is lacking and more precise stratification would be beneficial. We then suggest the proper usage of these terms within different contexts and scenarios, focusing mainly on the nomenclature as it relates to the domains of oncology, prenatal testing, and post-transplant surgery surveillance. We hope that these recommendations will serve as useful considerations towards the establishment of universal cfDNA nomenclature in the future. In addition, it is conceivable that many of these recommendations can be transposed to cell-free RNA nomenclature by simply exchanging “DNA” with “RNA” in each acronym/abbreviation. Similarly, when describing DNA and RNA collectively, the suffix can be replaced with “NAs” to indicate nucleic acids.
         datePublished:2020-10-29T00:00:00Z
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            Gene Function
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      headline:Towards systematic nomenclature for cell-free DNA
      description:Cell-free DNA (cfDNA) has become widely recognized as a promising candidate biomarker for minimally invasive characterization of various genomic disorders and other clinical scenarios. However, among the obstacles that currently challenge the general progression of the research field, there remains an unmet need for unambiguous universal cfDNA nomenclature. To address this shortcoming, we classify in this report the different types of cfDNA molecules that occur in the human body based on its origin, genetic traits, and locality. We proceed by assigning existing terms to each of these cfDNA subtypes, while proposing new terms and abbreviations where clarity is lacking and more precise stratification would be beneficial. We then suggest the proper usage of these terms within different contexts and scenarios, focusing mainly on the nomenclature as it relates to the domains of oncology, prenatal testing, and post-transplant surgery surveillance. We hope that these recommendations will serve as useful considerations towards the establishment of universal cfDNA nomenclature in the future. In addition, it is conceivable that many of these recommendations can be transposed to cell-free RNA nomenclature by simply exchanging “DNA” with “RNA” in each acronym/abbreviation. Similarly, when describing DNA and RNA collectively, the suffix can be replaced with “NAs” to indicate nucleic acids.
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            name:German Heart Centre, Technical University Munich
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               name:Institute for Laboratory Medicine, German Heart Centre, Technical University Munich, Munich, Germany
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               name:IRCM, Institute of Research in Oncology of Montpellier, Montpellier, France
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      name:Institute for Laboratory Medicine, German Heart Centre, Technical University Munich, Munich, Germany
      name:Thrive Earlier Detection Corp., Cambridge, USA
      name:IRCM, Institute of Research in Oncology of Montpellier, Montpellier, France
      name:INSERM, U1194, Montpellier, France
      name:University of Montpellier, Montpellier, France
      name:Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
      name:DRK Kliniken Berlin Mitte, Klinik für Innere Medizin, Pneumologie und Schlafmedizin, Berlin, Germany
      name:Fondazione “Enrico Puccinelli” Onlus, Perugia, Italy
      name:Reproductive Epidemiology Group, Murdoch Children’s Research Institute, Parkville, Australia
      name:Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia
      name:Department of Perinatal Medicine, Mercy Hospital for Women, Heidelberg, Australia
      name:Department of Obstetrics and Gynaecology, The Northern Hospital, Epping, Australia
      name:Institute for Laboratory Medicine, German Heart Centre, Technical University Munich, Munich, Germany
      name:IRCM, Institute of Research in Oncology of Montpellier, Montpellier, France
      name:INSERM, U1194, Montpellier, France
      name:University of Montpellier, Montpellier, France
      name:ICM, Regional Institute of Cancer of Montpellier, Montpellier, France

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