
CRAN . RSTUDIO . COM {
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Title:
CRAN: Package sffdr
Description:
Pleiotropy-informed significance analysis of genome-wide association studies (GWAS) with surrogate functional false discovery rates (sfFDR). The sfFDR framework adapts the fFDR to leverage informative data from multiple sets of GWAS summary statistics to increase power in study while accommodating for linkage disequilibrium. sfFDR provides estimates of key FDR quantities in a significance analysis such as the functional local FDR and q-value, and uses these estimates to derive a functional p-value for type I error rate control and a functional local Bayes
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Keywords {🔍}
sffdr, functional, lgpl, sffdrtgz, surrogate, false, discovery, rates, bass, sffdrzip, rrelease, roldrel, genomewide, association, studies, significance, analysis, gwas, framework, estimates, fdr, local, qvalue, wallace, doi, rcpp, andrew, aut, source, binaries, arm, pleiotropyinformed, adapts, ffdr, leverage, informative, data, multiple, sets, summary, statistics, increase, power, study, accommodating, linkage, disequilibrium, key, quantities, derive,
Topics {✒️}
genome-wide association studies readme news cran checks functional local fdr significance analysis leverage informative data key fdr quantities error rate control gz windows binaries andrew bass [aut gwas summary statistics post-gwas analyses canonical form https /ajbass/sffdr needscompilation sffdr results documentation zip macos binaries sffdr framework adapts org/package=sffdr functional p sffdr framework multiple sets increase power linkage disequilibrium fine mapping rcpp linkingto rcpp suggests rmarkdown published reference manual pdf vignettes r-devel r-release r-oldrel r-project sffdr author lgpl-3 [expanded lgpl] url package source tgz linking wallace gwas bass 32614/cran package https //cran sffdr zip lgpl-2 source tgz ffdr
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