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BIORXIV . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
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  6. Keywords
  7. Topics
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We are analyzing https://www.biorxiv.org/content/10.1101/2025.06.24.661167v1.

Title:
CMV reshapes lymphoid immunity in aging: a single-cell atlas with predictive modeling | bioRxiv
Description:
Cytomegalovirus (CMV), a common herpesvirus, establishes lifelong latency and increases in prevalence with age; yet its systemic impact on the aging immune system remains incompletely understood. We profiled circulating immune cells from healthy older adults (median age: 73) who were CMV(+) or CMV(-) using single-cell RNA-sequencing and validated key findings by flow cytometry. CMV(+) individuals exhibited significant expansion of adaptive immune cells: CD4⁺ and CD8⁺ TEMRA T, GZMK+ CD8⁺ T, γδ T, and atypical B cells. Among innate immune cells, monocytes and dendritic cells remained largely unchanged while KLRC2 + (adaptive) NK cells increased and CD56dim NK cells decreased. To facilitate CMV assessment in datasets with unknown CM serostatus, we developed CMVerify , a machine learning classifier that accurately predicts CMV serostatus from single-cell data across platforms and age groups (97% accuracy). These findings reveal extensive CMV-associated immune remodeling in older adults and underscore the importance of incorporating CMV status in studies of immune aging. ### Competing Interest Statement The A.G.-S. laboratory has received research support from Avimex, Dynavax, Pharmamar, 7Hills Pharma, ImmunityBio and Accurius, outside of the reported work. A.G.-S. has consulting agreements for the following companies involving cash and/or stock: Castlevax, Amovir, Vivaldi Biosciences, Contrafect, 7Hills Pharma, Avimex, Pagoda, Accurius, Esperovax, Applied Biological Laboratories, Pharmamar, CureLab Oncology, CureLab Veterinary, Synairgen, Paratus, Pfizer, Virofend and Prosetta, outside of the reported work. A.G.-S. has been an invited speaker in meeting events organized by Seqirus, Janssen, Abbott, Astrazeneca and Novavax. A.G.-S. is inventor on patents and patent applications on the use of antivirals and vaccines for the treatment and prevention of virus infections and cancer, owned by the Icahn School of Medicine at Mount Sinai, New York, outside of the reported work.
Website Age:
12 years and 2 months (reg. 2013-04-08).

Matching Content Categories {πŸ“š}

  • Science
  • Education
  • Health & Fitness

Content Management System {πŸ“}

What CMS is biorxiv.org built with?

Website use Drupal 7 (http://drupal.org).

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of biorxiv.org audience?

πŸ’₯ Very Strong Traffic: 200k - 500k visitors per month


Based on our best estimate, this website will receive around 261,717 visitors per month in the current month.

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How Does Biorxiv.org Make Money? {πŸ’Έ}

We can't figure out the monetization strategy.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Biorxiv.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {πŸ”}

cmv, biology, cells, immune, ags, medrxiv, subject, reviews, clinical, preprint, aging, singlecell, age, reported, work, cancer, biorxiv, university, trials, epidemiology, search, results, pdf, older, adults, findings, adaptive, serostatus, laboratory, research, support, avimex, pharmamar, hills, pharma, accurius, curelab, copyright, license, institute, technology, immunology, context, genetics, microbiology, papers, submitted, cookies, skip, main,

Topics {βœ’οΈ}

epidemiology subject categories single-cell data single-cell rna-sequencing clinical trials single-cell atlas biorxiv subject category genetics microbiology epidemiology papers reviews cancer author/funder keyword advanced search health-related information nk cells increased innate immune cells validated key findings unknown cm serostatus received research support djamel nehar-belaid chia-ling kuo cathleen colon-emeric adolfo garcΓ­a- sastre establishes lifelong latency machine learning classifier competing interest statement companies involving cash applied biological laboratories meeting events organized generous financial support chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior adaptive immune cells facilitate cmv assessment incorporating cmv status duygu ucar doi healthy older adults context immune aging immune remodeling older adults results follow luke trinity radu marches asa thibodeau giray eryilmaz emilie picard silke paust

Social Networks {πŸ‘}(4)

External Links {πŸ”—}(7)

Analytics and Tracking {πŸ“Š}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager

Libraries {πŸ“š}

  • Clipboard.js
  • jQuery
  • Modernizr

Emails and Hosting {βœ‰οΈ}

Mail Servers:

  • usb-smtp-inbound-1.mimecast.com
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Name Servers:

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CDN Services {πŸ“¦}

  • Jsdelivr

6.49s.