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We are analyzing https://www.biorxiv.org/content/10.1101/2025.06.23.660971v1.

Title:
The ZNF512B-NuRD complex co-ordinates a neural-specific gene expression program | bioRxiv
Description:
The nucleosome remodelling and deacetylase complex (NuRD) plays a key role in chromatin regulation and a wide range of biological processes including development, haemopoiesis, immunity and neurogenesis. Its interaction with tissue-enriched and sequence-specific transcription factors (TFs) leads to distinct functional outputs in the given tissue by targeting a specific set of genes. However, how NuRD dynamically and specifically regulates gene expression in a tissue-specific manner is poorly understood. Here, we refine an N-terminal specific NuRD interaction motif which enables direct engagement with many transcriptional regulatory proteins. Using a series of structural modelling and biochemical techniques, we show that ZNF512B, a poorly characterised neuronal-expressed zinc finger protein, directly binds to the RBBP4 subunit of the NuRD complex. Subsequent knockdown of ZNF512B results in the downregulation of several neural-related molecular pathways suggesting that ZNF512B may play a regulatory role during neurogenesis. We also show that in NTERA-2 neural cells, the expression of ZNF512B is necessary for cell growth and survival, and is markedly enhanced during neural progenitor cell (NPC) differentiation. In summary, our data suggest that ZNF512B might regulate neural-specific transcriptional programs via engagement with the NuRD complex. ### Competing Interest Statement The authors have declared no competing interest.
Website Age:
12 years and 2 months (reg. 2013-04-08).

Matching Content Categories {📚}

  • Education
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Content Management System {📝}

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Website use Drupal 7 (http://drupal.org).

Traffic Estimate {📈}

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💥 Very Strong Traffic: 200k - 500k visitors per month


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How Does Biorxiv.org Make Money? {💸}

We find it hard to spot revenue streams.

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Keywords {🔍}

biology, view, orcid, profile, nurd, znfb, complex, medrxiv, subject, reviews, clinical, results, preprint, expression, molecular, cell, biorxiv, university, trials, epidemiology, search, neuralspecific, gene, pdf, role, neurogenesis, interaction, specific, set, poorly, engagement, transcriptional, regulatory, show, neural, competing, interest, authors, copyright, license, institute, technology, cancer, context, genetics, microbiology, papers, submitted, cookies, skip,

Topics {✒️}

epidemiology subject categories clinical trials neural progenitor cell sequence-specific transcription factors biorxiv subject category genetics microbiology cell growth epidemiology papers reviews health-related information ntera-2 neural cells author/funder keyword advanced search tissue-specific manner transcriptional regulatory proteins distinct functional outputs generous financial support chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior enables direct engagement competing interest statement context specific set poorly understood znf512b-nurd complex competing interest nurd complex nurd dynamically regulatory role deacetylase complex results follow yue feng caroline giardina omar ibrahim nucleosome remodelling key role chromatin regulation wide range tissue-enriched structural modelling biochemical techniques directly binds rbbp4 subunit subsequent knockdown expression markedly enhanced data suggest

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  • Google Analytics
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Libraries {📚}

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Emails and Hosting {✉️}

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